- Clinical pharmacology review for primary health care providers: II. Steroids
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Han S
- KMID: 2148854
- Transl Clin Pharmacol.
- 2015 Jun;23(1):15-20.
- doi: 10.12793/tcp.2015.23.1.15
Primary health care providers play a critical role in maintaining public health, and the appropriate prescription of pharmaceutical products is a major component of their practice. This series of articles... -
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- Statistical basis for pharmacometrics: maximum likelihood estimator and its asymptotics
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Choi K, Yim DS
- KMID: 2148853
- Transl Clin Pharmacol.
- 2015 Jun;23(1):8-14.
- doi: 10.12793/tcp.2015.23.1.8
The maximum likelihood estimator is the point estimator of the top priority in statistical data analysis because of its optimum properties for large sample size. While the maximum likelihood estimator... -
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- R-based reproduction of the estimation process hidden behind NONMEM(R) Part 1: first-order approximation method
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Kim MG, Yim DS, Bae KS
- KMID: 2148852
- Transl Clin Pharmacol.
- 2015 Jun;23(1):1-7.
- doi: 10.12793/tcp.2015.23.1.1
NONMEM(R) is the most-widely used nonlinear mixed effects modelling tool introduced into population PK/PD analysis. Even though thousands of pharmaceutical scientists utilize NONMEM(R) routinely for their data analysis, the various... -
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- Assessment of statistical power for covariate effects in data from phase I clinical trials
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Kim Y, Son H, Son M, Lee D, Heo YA, Park K
- KMID: 2148857
- Transl Clin Pharmacol.
- 2015 Jun;23(1):31-34.
- doi: 10.12793/tcp.2015.23.1.31
One of the important purposes in population pharmacokinetic studies is to investigate the relationships between parameters and covariates to describe parameter variability. The purpose of this study is to evaluate... -
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- Bioequivalence of the pharmacokinetics between two formulations of 0.2 mg tamsulosin hydrochloride in healthy subjects
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Park SI, Rhee SJ, Jang IJ, Yu KS, Yim SV, Kim BH
- KMID: 2148855
- Transl Clin Pharmacol.
- 2015 Jun;23(1):21-25.
- doi: 10.12793/tcp.2015.23.1.21
Tamsulosin is an effective therapeutic option for lower urinary tract symptoms, as it selectively blocks alpha1A- and alpha1D-adrenoceptors in the bladder and prostate. The purpose of this study was to... -
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- Bioequivalence study of Donepezil hydrochloride in healthy Korean volunteers
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Choi Y, Rhee SJ, Jang IJ, Yu KS, Yim SV, Kim BH
- KMID: 2148856
- Transl Clin Pharmacol.
- 2015 Jun;23(1):26-30.
- doi: 10.12793/tcp.2015.23.1.26
Donepezil is a centrally acting, reversible acetylcholinesterase inhibitor that is widely used for treating Alzheimer's disease. This study aimed to compare the pharmacokinetics of Bastia(R), a test tablet formulation of... -
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