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Development of a LC-MS/MS for Quantification of Venlafaxine in Human Plasma and Application to Bioequivalence Study in healthy Korean Subjects

Kang HK, Kang MA, Kim HJ, Park YS, Kim SH, Kang JS

  • KMID: 2317857
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):35-42.
A simple, rapid and selective liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is developed and validated for quantification of venlafaxine in human plasma with simple liquid-liquid extraction step consisted...
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Genetic Polymorphisms of the Carboxylesterase 1 (CES1) Gene in a Korean Population

Cha YJ, Jeong HE, Shin JG, Kim EY, Yu KS, Cho JY, Yoon SH, Lim KS

  • KMID: 2317856
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):30-34.
Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyzes various exogenous compounds. Single nucleotide polymorphisms (SNPs) of CES1 may lead to inter-individual metabolic variability of its substrates. The allele...
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Pharmacokinetic Characteristics of Ibandronate and Tolerability of DP-R206 (150 mg Ibandronate/24,000 IU Vitamin D3) Compared to the Ibandronate (150 mg) Monotherapy in Healthy Adults

Choi HY, Kim MJ, Kim YH, Noh YH, Lee JW, Lee TW, Kim MG, Bae KS

  • KMID: 2317855
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):22-29.
Ibandronate (a bisphosphonate) is commonly used as an treatment of osteoporosis in combination with vitamin D. Monthly DP-R206-a novel, fixed-dose combination tablet (150 mg ibandronate/24,000 IU vitamin D3)-was recently developed...
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Pregnane X Receptor agonist Increases the Expression Levels of the Plasma Membrane Monoamine Transporter

Cho SK, Oh H, Hong SH, Park MS, Chung JY

  • KMID: 2317854
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):19-21.
We evaluated the effect of the pregnane X receptor agonist, pregnenolone 16 alpha-carbonitrile (PCN) on the expression levels of plasma monoamine transporter (PMAT) in the intestine. Male C57/BL6 mice were...
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Clinical Pharmacology Review for Primary Health Care Providers: I. Antihistamines

Han S

  • KMID: 2317853
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):13-18.
Primary health care providers play a critical role in maintaining public health, and the appropriate use of pharmaceutical products is one of the major parts of their practice. This series...
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Repeated Administration of Newly Synthesized Aceclofenac Sustained Release Form Causes Agranulocytosis: Case Report of an Unforeseen Adverse Event during the Phase 1 Trial

Jin H, Zheng R, Kim B, Yim SV

  • KMID: 2317852
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):11-12.
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) for inflammatory diseases. In this report, we report a serious adverse event (AE) occurred during the phase I clinical trial for a new...
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Pharmacometabolomics: Current Applications and Future Perspectives

Kim HJ, Yoon YR

  • KMID: 2317851
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):8-10.
Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical...
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CYP3A5*3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role

Park JY, Cha YJ, Kim KA

  • KMID: 2317850
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):3-7.
The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in...
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From JKSCPT to TCP

Yim DS

  • KMID: 2317849
  • Transl Clin Pharmacol.
  • 2014 Jun;22(1):1-1.
No abstract available.
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