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Factors influencing the transition shock of newly-graduated nurses

Moon KJ, Cho, MY

Purpose: The purpose of this study was to identify factors that can affect transition shock in newly-graduated nurses. Methods: The first descriptive written survey was conducted on 450 graduate students...
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Atorvastatin regulates the migration and invasion of prostate cancer through the epithelial-mesenchymal transformation and matrix metalloproteinase pathways

Zhu Z, Cao Y, Liu L, Zhao Z, Yin H, Wang H

Purpose: Our purpose was to verify the effects of atorvastatin (ATO) on prostate cancer (PCa) proliferation, apoptosis, invasion, and metastasis and to further explore the drug’s mechanism of action. Materials and...
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Metabolic Impacts of Discontinuation and Resumption of Recombinant Human Growth Hormone Treatment during the Transition Period in Patients with Childhood-Onset Growth Hormone Deficiency

Lee YJ, Choi Y, Yoo HW, Lee YA, Shin CH, Choi HS, Kim HS, Kim JH, Moon JE, Ko CW, Ahn MB, Suh BK, Choi JH

Background: Discontinuing growth hormone (GH) treatment during the transition to adulthood has been associated with adverse health outcomes in patients with childhood-onset growth hormone deficiency (CO-GHD). This study investigated the...
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Transitional care for high-risk elderly patients pre/post discharge by collaboration between general hospital and community pharmacy: a pilot study

Park MS, Lee JH, Lee HB, Kim JS, Choi EJ

Background: Medication-related problems (MRPs) frequently occur during the discharge period. Elderly patients, particularly, are at high risk for these problems due to polypharmacy and the use of potentially inappropriate medications....
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Concept analysis of transition to motherhood: a methodological study

Hwang WY, Choi SY, An HJ

Purpose: Although the term “transition to motherhood” is commonly used in research, the concept is not clear. This study, hence, was conducted to clarify the concept of “transition to motherhood.” Methods:...
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Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells

Shilnikova K, Piao MJ, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Cho SJ, Hyun JW

Radiation resistance represents an imperative obstacle in the treatment of patients with colorectal cancer, which remains difficult to overcome. Here, we explored the anti-proliferative and migration-inhibiting properties of the natural...
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Potentiation of the Anticancer Effects by Combining Docetaxel with Ku-0063794 against Triple-Negative Breast Cancer Cells

Jeon YW, Kim OH, Shin JS, Hong HE, Kim CH, Kim SJ

Purpose mTORC1 and mTORC2 inhibition by Ku-0063794 could confer profound anticancer effects against cancer cells because it eliminates feedback activation of Akt. Herein, we aimed to determine anticancer effects of...
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Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/ AKT/mTOR/HIF-1α Signaling Pathway

Zhou P, Zheng ZH, Wan T, Wu J, Liao CW, Sun XJ

Purpose: Gastric cancer (GC) has high morbidity and mortality and is a serious threat to public health. The flavonoid compound vitexin is known to exhibit anti-tumor activity. In this study,...
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Cooperative Subtype Switch of Thyroid Hormone Receptor and Nuclear Receptor Corepressor Related Epithelial–Mesenchymal Transition in Papillary Thyroid Cancer

Jeong S, Lee SG, Kim H, Lee G, Park S, Kim IK, Lee J, Jo YS

Background and Objectives: Although thyroid hormones affect human cancer progression, the regulatory mechanism of thyroid hormone receptors in carcinogenesis has not been elucidated. This study aimed to evaluate the expression...
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Transition Experiences of the Elderly from Long-Term Care Hospital to Home: Focusing on the Elderly Living Alone of Community Care Project

Hwang YH, Lee GE

Purpose: The purpose of this qualitative study was to explore the transition experiences of the elderly from long-term care hospitals to their homes. Methods: The participants were eight elderly medicaid...
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Mitofusin-2 Promotes the EpithelialMesenchymal Transition-Induced Cervical Cancer Progression

Ahn SY, Song J, Kim YC, Kim MH, Hyun YM

High expression of mitofusin-2 (MFN2), a mitochondrial fusion protein, has been frequently associated with poor prognosis of patients with cervical cancer. Here, we aimed to identify the function of MFN2...
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Diabetes in Adolescence, Appropriate Transition to Adult Clinic

Lee J, Kim JH

As the prevalence of diabetes in children and adolescents increases, the transition of diabetes care from childhood to adulthood is increasing. During the transition period, the risks for hypoglycemia and...
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Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells

Lee DY, Song MY, Kim EH

Gastric cancer is a malignancy with high incidence and mortality worldwide. In gastric cancer, epithelial-mesenchymal transition (EMT) and metastasis further increase the mortality rate. Trefoil factor 1 (TFF1) has been...
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Comparative study: nonsynonymous and synonymous substitution of SARS-CoV-2, SARS-CoV, and MERS-CoV genome

Sohpal VK

The direction of evolution can estimate based on the variation among nonsynonymous to synonymous substitution. The simulative study investigated the nucleotide sequence of closely related strains of respiratory syndrome viruses,...
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A national survey of transition from pediatric to adult healthcare providers for adolescents and young adults with type 1 diabetes: perspectives of pediatric endocrinologists in Korea

Kim JH, Yoo JH

Purpose: Transition from pediatric to adult healthcare for adolescents and young adults with type 1 diabetes (T1D) increases the risk for poor outcomes. This study aimed to describe the circumstances...
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How Can We Do Transition Successfully from Pediatric to Adult Clinics in Inflammatory Bowel Disease?  

Kim MJ, Hong SN, Kim YH, Choe YH

With the increasing incidence of pediatric inflammatory bowel disease (IBD) in children and its impact throughout life, transition care has become an important issue. In Korea, no guidelines have been...
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Cell Lineage, Self-Renewal, and Epithelial-to-Mesenchymal Transition during Secondary Neurulation

Kawachi T, Tadokoro R, Takahashi Y

Secondary neurulation (SN) is a critical process to form the neural tube in the posterior region of the body including the tail. SN is distinct from the anteriorly occurring primary...
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Challenges of the patient transition process from the intensive care unit: a qualitative study

Ghorbanzadeh K, Ebadi A, Hosseini M, Madah SSB, Khankeh H

Background: The transition of patients from the intensive care unit (ICU) to the general ward is challenging. This study aimed to explain the challenges that patients face during the transition...
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Ginsenoside Rb1 Attenuates TGF-β1-Induced MUC4/5AC Expression and Epithelial-Mesenchymal Transition in Human Airway Epithelial Cells

Choi TY, Kim JH, Jo S, Lee S, Na HG, Choi YS, Song SY, Kim YD, Bae CH

Background and Objectives Ginsenoside Rb1 is the main metabolite of Panax ginseng. It is known to have many beneficial properties including anti-inflammatory, antitumoral and antioxidant effects. However, the therapeutic effects...
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Autophagy inhibition by cudraxanthone D regulates epithelial–mesenchymal transition in SCC25 cells

Yu SB, Bang TH, Kang HM, Park BS, Kim IR

Cudraxanthone D (CD) is a natural xanthone compound derived from the root barks of Cudrania tricuspidata . However, the biological functions of CD in human metabolism have been rarely reported...
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