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Oxidized LDL is a Chemoattractant for the Eosinophils and Neutrophils

Hwang YS, Lee JD, Busse WB

BACKGROUND: Rhinovirus infection of the airways results in increased permeability of the airway vascular endothelium with the influx of plasma proteins, including lipids such as LDL. In vitro studies on...
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Entry of Lymphocytes into the Brain and Expression of ICAM-1 on the Brain Endothelium

Lee EY, Jin LJ, Lee GK

  • KMID: 2092839
  • Korean J Anat.
  • 2004 Oct;37(5):431-439.
To evaluate the entry of lymphocytes into the brain, we isolated lymphocytes from non-immunized Balb/C mice spleens and activated lymphocytes with anti-CD3 and anti-CD28 antibodies. Activated lymphocytes were labeled with...
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Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury

Kim SC, Ko YS, Lee HY, Kim MG, Jo SK, Cho WY

BACKGROUND/AIMS: Recent findings have demonstrated the occurrence of neutrophil transendothelial migration in the reverse direction (reverse TEM) and that endothelial junctional adhesion molecule C (JAM-C) is a negative regulator of...
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Effects of Transmigration of Bone Marrow Nuclear Cells Through Endothelial Cell and Stromal Cell by Leukotriene B4 and Inhibition of Reactive Oxygen Species

Mun YC, Oh SA, Lee KE, Yoo ES, Choi MY, Ahn JY, Seong CM

OBJECTIVES: Leukotriene B4(LTB4) is lipid mediator derived from membrane phospholipids during the process of inflammation, having many roles(ie; inducer of chemotaxis, the production of nitric oxide, transepithelial migration of neutrophil)....
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Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils

Kim BJ, Kim JY, Hwang ES, Kim JG

BACKGROUND/AIMS: The cytosolic host protein nucleotide binding oligomerization domain 1 (Nod1) has emerged as a key pathogen recognition molecule for innate immune responses in epithelial cells. The purpose of the...
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Resveratrol blunts tumor necrosis factor-alpha-induced monocyte adhesion and transmigration

Kim DS, Kwon HM, Choi JS, Kang SW, Ji GE, Kang YH

  • KMID: 2313328
  • Nutr Res Pract.
  • 2007 Dec;1(4):285-290.
The leukocyte recruitment and transmigration across the endothelial barrier into the vessel wall are crucial steps in atherosclerosis. Leukocyte trafficking on the endothelium is elicited by induction of endothelial adhesion...
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Study on Role of Neutrophil in Endothelial Cell Injury under High Glucose Condition

Son SM, Kim IJ, Kim YK

  • KMID: 1767981
  • J Korean Diabetes Assoc.
  • 2000 Dec;24(6):652-665.
BACKGROUND: High glucose level plays a major role in the injury of endothelium during the early event in diabetic vascular complication. It was speculated that high glucose level may cause...
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Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury

Cho W, Song JY, Oh SW, Kim MG, Ko YS, Lee HY, Jo SK

Effective clearance of inflammatory cells is required for resolution of inflammation. Here, we show in vivo evidence that apoptosis and reverse transendothelial migration (rTEM) are important mechanisms in eliminating neutrophils...
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Effect of Oxidized LDL on Neutrophil Adhesion and Transendothelial Migration

Son SM, Kim IJ, Kim YK

  • KMID: 2177974
  • J Korean Diabetes Assoc.
  • 1999 Feb;23(1):12-24.
BACKGROUND: It is well recognized that oxidized low density lipoproteins (ox-LDL) play a critical role in the pathogenesis of atherosclerosis. The activation of circulating leukocytes and their adhesion to the...
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KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model

Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT

  • KMID: 1402317
  • Exp Mol Med.
  • 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive...
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Effects of Short-Term Incubation of Hematopoietic Cells with Hematopoietic Growth Factors on CXCR4 Expression and Stromal Cell-Derived Factor-1-Mediated Transendothelial Migration

Jo DY, Hwang JH, Kwak SK, Shin HY, Kim SE, Yun HJ, Seong CM, Kim SY

  • KMID: 2143334
  • Korean J Hematol.
  • 2001 Nov;36(4):324-334.
BACKGROUND: There has been contradictory reports regarding the homing potential of hematopoietic cells briefly exposed to hematopoietic growth factors in vitro. To get a resolution to this controversy, we...
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Regulation of Adhesion Molecule Expression and Stromal Cell-Derived Factor-1 Production in Human Bone Marrow Cells by Interferon-gamma, Tumor Necrosis Factor-alpha, and Transforming Growth Factor-beta1: Implications in Bone Marrow Homing of Hematopoietic Cells

Jo DY, Hwang JH, Chung HK, Park SE, Park SJ, Kwak SK, Yun HJ, Seong CM, Kim S

  • KMID: 2014031
  • Korean J Hematol.
  • 2003 May;38(2):91-99.
BACKGROUND: It is well known that harmonious interactions among adhesion molecules and stromal cell-derived factor-1 (SDF-1)-mediated chemoattraction signalling via CXCR4 are needed for bone marrow homing of hematopoietic stem cells...
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Circulating Cell Adhesion Molecules in Patients with Type 2 Diabetes Mellitus

Cha YJ, Chae SL, Kim CH

  • KMID: 2226058
  • Korean J Clin Pathol.
  • 2002 Feb;22(1):52-56.
BACKGROUND: Cell adhesion molecules (CAMs) have been shown to be highly expressed in atherosclerotic lesions. Membrane-bound CAMs allow the tethering and rolling of monocytes and lymphocytes as well as the...
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A Study of Receptor Expression in Leukocytes by Quantitative Fluorescence Measurement

Kim KH, Seoh JY

  • KMID: 2335639
  • J Korean Pediatr Soc.
  • 2002 May;45(5):637-645.
PURPOSE: It is well known that the receptors for Fcgamma moiety of IgG(FcgammaR) are instrumental in antibody-mediated clearance of microorganisms by granulocytes and monocytes, and immune regulation in lymphocytes. Furthermore,...
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Solyble ICAM-1 and BCAM-1 in Patients with NIDDM

Kim YM, Kim YG, Son SM, Kim IJ, Yoo SD, Choi YK, Lee CW, Ahn JH

  • KMID: 2063344
  • J Korean Diabetes Assoc.
  • 1999 Jun;23(3):315-325.
BACKGROUND: The development of vascular complications in diabetic patients changess their quality of life, as well as shortens their life expectancy. It has been recently discovered that the expressions of...
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Blockade of vascular angiogenesis by Aspergillus usamii var. shirousamii-transformed Angelicae Gigantis Radix and Zizyphus jujuba

Kang SW, Choi JS, Bae JY, Li J, Kim DS, Kim JL, Shin SY, You HJ, Park HS, Ji GE, Kang YH

  • KMID: 2313370
  • Nutr Res Pract.
  • 2009 Mar;3(1):3-8.
The matrix metalloproteinases (MMP) play an important role in tumor invasion, angiogenesis and inflammatory tissue destruction. Increased expression of MMP was observed in benign tissue hyperplasia and in atherosclerotic lesions....
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