- Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
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Park JS, Chang DY, Kim JH, Jung JH, Park J, Kim SH, Lee YD, Kim SS, Suh-Kim H
- KMID: 2154229
- Exp Mol Med.
- 2013 Feb;45(2):e10.
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability... -
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- Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector
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Kim ES, Kang M, Park HW, Kim MH
- KMID: 1052937
- Exp Mol Med.
- 2008 Apr;40(2):151-160.
- doi: 10.3858/emm.2008.40.2.151
In order to examine whether the Hoxc8 protein can deliver nucleic acid into mammalian cells, we designed several Hoxc8-derived recombinant proteins to be synthesized as glutathione S-transferase (GST) fused forms... -
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- T Cell-specific Immunosuppression Using Tautomycetin or PTD-conjugated Protein Drugs
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Chae WJ, Choi JM, Yang JJ, Lee SK
- KMID: 1726159
- Yonsei Med J.
- 2004 Dec;45(6):978-990.
- doi: 10.3349/ymj.2004.45.6.978
No abstract available. -
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- Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine
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Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY
- KMID: 755664
- Exp Mol Med.
- 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine... -
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- Delivery of Factor VIII Gene into Skeletal Muscle Cells Using Lentiviral Vector
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Jeon HJ, Oh TK, Kim OH, Kim ST
- KMID: 1779606
- Yonsei Med J.
- 2010 Jan;51(1):52-57.
- doi: 10.3349/ymj.2010.51.1.52
PURPOSE: This study was designed to investigate whether transduction of lentiviral vectors (LV) carrying human coagulation factor VIII (hFVIII) cDNA into skeletal muscle could increase circulating hFVIII concentrations. MATERIALS AND... -
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- Low-dose radiation response of the p21(WAF1/CIP1) gene promoter transduced by adeno-associated virus vector
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Nenoi M, Daino K, Ichimura S, Takahash S, Akuta T
- KMID: 1098090
- Exp Mol Med.
- 2006 Oct;38(5):553-564.
In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the promising approaches for tumor-specific gene delivery. Although... -
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- Secretion of Biologically Active Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor by Transduced Gastric Cancer Cells
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Kim HY, Park GS, Shin HJ, Park S, Kim K, Kim HI
- KMID: 1084502
- Yonsei Med J.
- 2008 Apr;49(2):279-287.
- doi: 10.3349/ymj.2008.49.2.279
PURPOSE: Gastric cancer has the highest incidence rate among cancers in Asia. The advanced type of signet ring cell carcinoma has poor prognosis compared to other types of gastric cancer.... -
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- In vitro induction of anterior gradient-2-specific cytotoxic T lymphocytes by dendritic cells transduced with recombinant adenoviruses as a potential therapy for colorectal cancer
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Lee HJ, Hong CY, Kim MH, Lee YK, Nguyen-Pham TN, Park BC, Yang DH, Chung IJ, Kim HJ, Lee JJ
- KMID: 1120143
- Exp Mol Med.
- 2012 Jan;44(1):60-67.
- doi: 10.3858/emm.2012.44.1.006
Anterior gradient-2 (AGR2) promotes tumor growth, cell migration, and cellular transformation, and is one of the specific mRNA markers for circulating tumor cells in patients with gastrointestinal cancer. We investigated... -
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- Introduction of the CIITA gene into tumor cells produces exosomes with enhanced anti-tumor effects
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Lee YS, Kim SH, Cho JA, Kim CW
- KMID: 1009967
- Exp Mol Med.
- 2011 May;43(5):281-290.
- doi: 10.3858/emm.2011.43.5.029
Exosomes are small membrane vesicles secreted from various types of cells. Tumor-derived exosomes contain MHC class I molecules and tumor-specific antigens, receiving attention as a potential cancer vaccine. For induction... -
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- Increased Anti-tumor Effect by a Combination of HSV Thymidine Kinase Suicide Gene Therapy and Interferon-gamma/GM-CSF Cytokine Gene Therapy in CT26 Tumor Model
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Yang SH, Oh TK, Kim ST
- KMID: 2157739
- J Korean Med Sci.
- 2005 Dec;20(6):932-937.
- doi: 10.3346/jkms.2005.20.6.932
The potential therapeutic benefit of introducing IFN-gamma and GM-CSF genes in combination with the HSVtk suicide gene into subcutaneously implanted CT26 tumor cells was compared with that from each treatment... -
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- Evidence that the fully assembled capsid of Leishmania RNA virus 1-4 possesses catalytically active endoribonuclease activity
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Ro YT, Kim EJ, Lee HI, Saiz M, Jr RC, Patterson
- KMID: 1380209
- Exp Mol Med.
- 2004 Apr;36(2):145-156.
In this study, Leishmania RNA virus 1-4 (LRV1-4) particles purified from host Leishmania guyanensis promastigotes were examined for capsid endoribonuclease. Temperature optimum for the endoribonulease activity was found to be... -
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