- Gene expression profiling of light-induced retinal degeneration in phototransduction gene knockout mice
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Krishnan J, Chen J, Shin KJ, Hwang JI, Han SU, Lee G, Choi S
- KMID: 1104803
- Exp Mol Med.
- 2008 Oct;40(5):495-504.
- doi: 10.3858/emm.2008.40.5.495
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-),... -
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- Stimulation of Glucagon Like Peptide-1 Secretion in Enteroendocrine L cells
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Kim BJ
- KMID: 2298050
- Korean Diabetes J.
- 2009 Dec;33(6):458-463.
- doi: 10.4093/kdj.2009.33.6.458
GLP-1 (glucagon like peptide-1) is new anti-diabetic drug with a number of beneficial effects. It stimulates glucose dependant insulin secretion and restoration of beta cell mass through enhancement of islet... -
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- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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