- Interferon-gamma upregulates the stromelysin-1 gene expression by human skin fibroblasts in culture
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Lee KS, Ryoo YW, Song JY
- KMID: 754989
- Exp Mol Med.
- 1998 Jun;30(2):59-64.
The equilibrium between deposition and degradation of extracellular matrix(ECM) is essential to normal tissue development and repair of wound or inflammatory responses. It has recently become apparent that several cytokines and growth factors... -
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- B6C3F1 mice exposed to ozone with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-kappaB, AP-1, Nrf2, and osteopontin
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Kim MY, Song KS, Park GH, Chang SH, Kim HW, Park JH, Jin H, Eu KJ, Cho HS, Kang G, Kim YC, Cho MH
- KMID: 1120069
- J Vet Sci.
- 2004 Jun;5(2):131-137.
Toxic effects of ozone, 4-(N-methyl-N-nitrosamino)-1-(3- pyridyl)-1-butanone (NNK), and/or dibutyl phthalate (DBP) were examined through NF-kappaB, AP-1, Nrf2, and osteopontin (OPN) in lungs and livers of B6C3F1 mice. Electrophoretic mobility shift... -
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- Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells
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Lee KJ, Kim YM, Kim DY, Jeoung D, Han K, Lee ST, Lee YS, Park KH, Park JH, Kim DJ, Hahn JH
- KMID: 1110120
- Exp Mol Med.
- 2006 Aug;38(4):364-374.
Heat shock protein 70 (Hsp70) release and its effects on pro-inflammatory cytokine production have been controversial. In this study, we investigated whether Hsp70 could be released from monocytes and activates... -
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- Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells
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Hong IK, Kim YM, Jeoung DI, Kim KC, Lee H
- KMID: 1056236
- Exp Mol Med.
- 2005 Jun;37(3):230-239.
Expression of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), which correlates with tumor invasion and metastasis, has been known to be regulated by several intracellular signaling pathways. Since the CD9... -
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- Inhibitory effect of (-)-epigallocatechin gallate on titanium particle-induced TNF-alpha release and in vivo osteolysis
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Jin S, Park JY, Hong JM, Kim TH, Shin HI, Park EK, Kim SY
- KMID: 1015460
- Exp Mol Med.
- 2011 Jul;43(7):411-418.
- doi: 10.3858/emm.2011.43.7.045
Tumor necrosis factor-alpha (TNF-alpha) and inflammatory cytokines released from activated macrophages in response to particulate debris greatly impact periprosthetic bone loss and consequent implant failure. In the present study, we... -
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- Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
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Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G
- KMID: 1104812
- Exp Mol Med.
- 2008 Oct;40(5):574-581.
- doi: 10.3858/emm.2008.40.5.574
In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its... -
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- Activation of calcium signaling by hepatitis B virus-X protein in liver cells
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Oh JC, Jeong DL, Kim IK, Oh SH
- KMID: 1109320
- Exp Mol Med.
- 2003 Aug;35(4):301-309.
Hepatitis B virus x gene product (HBx) is known to be a transactivator of transcriptional elements that regulate the expression of a variety of genes associated with the growth, differentiation,... -
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- Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
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Kim HW, Kim YO, Yoon SA, Han JS, Chun HB, Kim YS
- KMID: 2373780
- Korean J Intern Med.
- 2016 Jan;31(1):116-124.
- doi: 10.3904/kjim.2016.31.1.116
BACKGROUND/AIMS: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2... -
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- Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
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Choi YJ, Kim SY, Oh JM, Juhnn YS
- KMID: 1119325
- Exp Mol Med.
- 2009 Aug;41(8):592-600.
- doi: 10.3858/emm.2009.41.8.065
Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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