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Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells

Jung HW, Chung YS, Kim YS, Park YK

  • KMID: 1091066
  • Exp Mol Med.
  • 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as...
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