- In Vivo Target RNA Specificity of Trans-Splicing Phenomena by the Group I Intron
-
Song MS, Lee SW
- KMID: 2166344
- Genomics Inform.
- 2008 Jun;6(2):84-86.
The Tetrahymena group I intron has been shown to employ a trans-splicing reaction and has been modified to specifically target and replace human telomerase reverse transcriptase (hTERT) RNA with a... -
- CITED
-
- Close
- SHARE
-
- Close
- Specificity of Intracellular Trans-Splicing Reaction by hTERT-Targeting Group I Intron
-
Jung HS, Kwon BS, Lee SW
- KMID: 2284678
- Genomics Inform.
- 2005 Dec;3(4):172-174.
Recent anti-cancer approaches have been based to target tumor-specifically associated and/or causative molecules such as RNAs or proteins. As this specifically targeted anti-cancer modulator, we have previously described a novel... -
- CITED
-
- Close
- SHARE
-
- Close
- Functional Modification of a Specific RNA with Targeted Trans-Splicing
-
Park YH, Kim SC, Kwon BS, Jung HS, Kimm K, Lee SW
- KMID: 1974010
- Genomics Inform.
- 2004 Mar;2(1):45-52.
The self-splicing group I intron from Tetrahymena thermophila has been demonstrated to perform splicing reaction with its substrate RNA in the trans configuration. In this study, we explored the potential... -
- CITED
-
- Close
- SHARE
-
- Close
- Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme
-
Song MS, Jeong JS, Cho KS, Lee SW
- KMID: 1091067
- Exp Mol Med.
- 2007 Dec;39(6):722-732.
A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in... -
- CITED
-
- Close
- SHARE
-
- Close
- An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
-
Song MS, Lee SW
- KMID: 2166253
- Genomics Inform.
- 2007 Mar;5(1):32-35.
Telomerase reverse transcriptase (TERT) is an enzymatic ribonucleoprotein that prolongs the replicative life span of cells by maintaining protective structures at the ends of eukaryotic chromosomes. Telomerase activity is highly... -
- CITED
-
- Close
- SHARE
-
- Close
- ChimerDB - Database of Chimeric Sequences in the GenBank
-
Kim N, Shin S, Cho KH, Lee S
- KMID: 2166166
- Genomics Inform.
- 2004 Jun;2(2):61-66.
Fusion proteins resulting from chimeric sequences are excellent targets for therapeutic drug development. We developed a database of chimeric sequences by examining the genomic alignment of mRNA and EST sequences... -
- CITED
-
- Close
- SHARE
-
- Close
