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Clinical applications of mesenchymal stem cells

Kim N, Cho SG

Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes. In addition, MSCs can...
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Cell Therapy for Diabetic Neuropathy Using Adult Stem or Progenitor Cells

Han JW, Sin MY, Yoon YS

Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments...
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Counteracting the enzymatic activity of dipeptidylpeptidase 4 for potential therapeutic advantage, with an emphasis on cord blood transplantation

Broxmeyer

Dipeptidylpeptidase (DPP) 4, also known as CD26, is an enzyme present on the surface of a number of different cell types. It is also found within cells and as a...
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Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ

Reagan MR, Seib FP, McMillin D, Sage EK, Mitsiades , Janes SM, Ghobrial I, Kaplan DL

PURPOSE: Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained...
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Strategy for Maximizing Therapeutic Efficacy of Adult Stem Cells

Koh SH

Stem cells have been suggested for the treatment of intractable neurological diseases. In spite of numerous clinical trials using autologous mesenchymal stem cells (MSCs), unfortunately, clinical efficacy has not yet...
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Clinical Applications of Neural Stem Cells for the Treatment of Peripheral Neuropathy

Park JM, Choi BO

Extraordinary advances in stem cell research have initiated an era of hope for strategies to treat intractable human diseases. Personalized regenerative treatment using stem cells is expected to accelerate continuous...
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Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery

Jang J, Yoo JE, Lee JA, Lee DR, Kim JY, Huh YJ, Kim DS, Park CY, Hwang DY, Kim HS, Kang HC, Kim DW

The generation of disease-specific induced pluripotent stem cell (iPSC) lines from patients with incurable diseases is a promising approach for studying disease mechanisms and drug screening. Such innovation enables to...
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Functional improvement of porcine neonatal pancreatic cell clusters via conformal encapsulation using an air-driven encapsulator

Park SJ, Shin S, Koo OJ, Moon JH, Jang G, Ahn C, Lee BC, Yoo YJ

Transplantation of islet cells into diabetic patients is a promising therapy, provided that the islet cells are able to evade host immune rejection. With improved islet viability, this strategy may...
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Trends and clinical application of induced pluripotent stem cells

Yoon BS, You S

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed into a pluripotent state by introducing defined transcription factors. iPSCs show...
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Effective Delivering Method of Umbilical Cord Blood Stem Cells in Cutaneous Wound Healing

Park SE, Han SB, Rah DK, Lew DH

  • KMID: 2322196
  • J Korean Soc Plast Reconstr Surg.
  • 2009 Sep;36(5):519-524.
PURPOSE: This study was conducted to identify the most effective method in cell therapy by comparing and analyzing the level of wound healing after the application of various cell delivery...
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Migration of human neural stem cells toward an intracranial glioma

Jeon JY, An JH, Kim SU, Park HG, Lee MA

Many in vivo and in vitro studies have demonstrated the targeted migration of neural stem cells (NSC) to infiltrating brain tumors, including malignant glioma, highlighting a potential therapeutic approach. However,...
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Isolation of neural precursor cells from skeletal muscle tissues and their differentiation into neuron-like cells

Park JS, Kim S, Han DK, Lee JY, Ghil SH

  • KMID: 756071
  • Exp Mol Med.
  • 2007 Aug;39(4):483-490.
Skeletal muscle contains several precursor cells that generate muscle, bone, cartilage and blood cells. Although there are reports that skeletal muscle-derived cells can trans-differentiate into neural-lineage cells, methods for isolating...
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Three-Dimensional Approach to Stem Cell Therapy

Oh IH, Kim DW

Recent progress in stem cell research is opening a new hope for cell therapy in regenerative medicine. Two breakthroughs were made in the stem cell era, one, new discoveries in...
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