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An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications

Sharma R, Kumar S, B, Gupta A, Dheer N, Jain P, Singh P, Kumar V

Tissue engineering is a research domain that deals with the growth of various kinds of tissues with the help of synthetic composites. With the culmination of nanotechnology and bioengineering, tissue...
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The Progress of Stem Cell Therapy in Myocardial-Infarcted Heart Regeneration: Cell Sheet Technology

Munderere R, Kim SH, Kim C, Park SH

Various tissues, including the heart, cornea, bone, esophagus, bladder and liver, have been vascularized using the cell sheet technique. It overcomes the limitations of existing techniques by allowing small layers...
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Progress of Polysaccharide-Contained Polyurethanes for Biomedical Applications

Ju DB, Lee JC, Hwang SK, Cho CS, Kim HJ

Polyurethane (PU) has been widely examined and used for biomedical applications, such as catheters, blood oxygenators, stents, cardiac valves, drug delivery carriers, dialysis devices, wound dressings, adhesives, pacemaker, tissue engineering,...
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Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids

Ou M, Li Q, Ling X, Yao J, Mo X

Oral and maxillofacial organoids (OMOs), tiny tissues and organs derived from stem cells cultured through 3-d cell culture models, can fully summarize the cell tissue structure, physiological functions and biological...
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Decellularized Human Adipose Tissue as an Alternative Graft Material for Bone Regeneration

Ahn WB, Lee YB, Ji YH, Moon KS, Jang HS, Kang SW

BACKGROUND: Tissue engineering approaches to treat damaged bone include various tissue transplants such as autologous, allogeneic, and xenografts. Artificial materials have been widely introduced to meet the demand for graft...
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In Situ-Forming Collagen/poly-γ-glutamic Acid Hydrogel System with Mesenchymal Stem Cells and Bone Morphogenetic Protein-2 for Bone Tissue Regeneration in a Mouse Calvarial Bone Defect Model

Cho SH, Shin KK, Kim SY, Cho MY, Oh DB, Lim YT

BACKGROUND: Bone marrow-derived mesenchymal stem cells (BMSCs) and bone morphogenetic protein-2 (BMP-2) have been studied for bone repair because they have regenerative potential to differentiate into osteoblasts. The development of...
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Graded-Three-Dimensional Cell-Encapsulating Hydrogel as a Potential Biologic Scaffold for Disc Tissue Engineering

Li Z, Zhang Y, Zhao Y, Gao X, Zhu Z, Mao Y, Qian T

BACKGROUND: Intervertebral disk (IVD) degeneration, which can cause lower back pain, is a major predisposing factor for disability and can be managed through multiple approaches. However, there is no satisfactory...
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Lytic Bacteriophage as a Biomaterial to Prevent Biofilm Formation and Promote Neural Growth

Liu ZH, Chiang MT, Lin HY

BACKGROUND Although non-lytic filamentous bacteriophages have been made into biomaterial to guide tissue growth, they had limited ability to prevent bacterial infection. In this work a lytic bacteriophage was used...
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Basic Fibroblast Growth Factor Induces Cholinergic Differentiation of Tonsil-Derived Mesenchymal Stem Cells

Song JH, Oh SY, Jo SA

BACKGROUND: Mesenchymal stem cells (MSCs) are considered a potential tool for regenerating damaged tissues due to their great multipotency into various cell types. Here, we attempted to find the appropriate...
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Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging

Wu JY, Wu SN, Zhang LP, Zhao XS, Li Y, Yang QY, Yuan RY, Liu JL, Mao HJ, Zhu NW

Senescence is an inevitable natural life process that involves structural and functional degeneration of tissues and organs. Recently, the process of skin aging has attracted much attention. Determining a means...
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Long Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect

Zhao X, Cui DJ, Yang Lc, Yuan WQ, Yan F

BACKGROUND: This study commenced to uncover the role of long non-coding RNA FBXL19 antisense RNA 1 (FBXL19-AS1) in the development of ulcerative colitis (UC) and its possible mechanism. METHODS: FBXL19-AS1 expression...
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Adenosine-Prefabricated Adipose Tissue Improves Fat Graft Survival by Promoting VEGF-Dependent Angiogenesis

Chang J, Song WJ, Soedono S, Sharlene S, Kim YJ, Choi CY, Cho KW

BACKGROUND: Angiogenesis plays an important role in determining the fat graft survival. However, clinical preconditioning techniques that target angiogenesis during fat grafting have not been established so far. Adenosine has...
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A Comprehensive Cancer-Associated MicroRNA Expression Profiling and Proteomic Analysis of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes

Jothimani G, Pathak S, Dutta S, Duttaroy AK, Banerjee A

BACKGROUND: The mesenchymal stem cells (MSCs) have enormous therapeutic potential owing to their multi-lineage differentiation and self-renewal properties. MSCs express growth factors, cytokines, chemokines, and non-coding regulatory RNAs with immunosuppressive,...
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Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells

Kotasová H, apandová M, Pelková V, Dumková J, Koledová Z, Remsˇı ´k J, Soucˇek K, Garlı´ková Z, Sedláková V, Rabata A, Vanˇhara P, Morán L, Pecˇinka L, Porokh V, Kucˇı´rek M, Streit L, Havel J, Hampl A

BACKGROUND The progenitors to lung airway epithelium that are capable of long-term propagation may represent an attractive source of cells for cell-based therapies, disease modeling, toxicity testing, and others. Principally,...
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