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Galectin-9 is Involved in Immunosuppression Mediated by Human Bone Marrow-derived Clonal Mesenchymal Stem Cells

Kim SN, Lee HJ, Jeon MS, Yi T, Song SU

Bone marrow-derived mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress exaggerated pro-inflammatory immune responses. Although the exact mechanisms remain unclear, a variety of soluble factors are known to...
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Identification of CCL1 as a Gene Differentially Expressed in CD4+ T Cells Expressing TIM-3

Jun KJ, Lee MJ, Shin DC, Woo MY, Kim K, Park S

BACKGROUND: T cell immunoglobulin mucin containing molecule (TIM)-3 is expressed in differentiated Th1 cells and is involved in the suppression of the cytokine production by these cells. However, the regulation...
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T-Cell Dysfunction and Inhibitory Receptors in Hepatitis C Virus Infection

Lee J, Suh WI, Shin EC

Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional...
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The Binding Properties of Glycosylated and Non-Glycosylated Tim-3 Molecules on CD4+CD25+ T Cells

Lee MJ, Heo YM, Hong SH, Kim K, Park S

BACKGROUND: T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown...
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Molecular variations in Th1-specific cell surface gene Tim-3

Chae SC, Song JH, Pounsambath P, Yuan HY, Lee JH, Kim JJ, Lee YC, Chung HT

  • KMID: 1097110
  • Exp Mol Med.
  • 2004 Jun;36(3):274-278.
The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, Tim-3 (T cell immunoglobulin mucin 3)...
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