- Increased Anti-tumor Effect by a Combination of HSV Thymidine Kinase Suicide Gene Therapy and Interferon-gamma/GM-CSF Cytokine Gene Therapy in CT26 Tumor Model
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Yang SH, Oh TK, Kim ST
- KMID: 2157739
- J Korean Med Sci.
- 2005 Dec;20(6):932-937.
- doi: 10.3346/jkms.2005.20.6.932
The potential therapeutic benefit of introducing IFN-gamma and GM-CSF genes in combination with the HSVtk suicide gene into subcutaneously implanted CT26 tumor cells was compared with that from each treatment... -
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- Imaging of Viral Thymidine Kinase Gene Expression by Replicating Oncolytic Adenovirus and Prediction of Therapeutic Efficacy
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Kim EJ, Yoo JY, Choi YH, Ahn KJ, Lee JD, Yun CO, Yun M
- KMID: 2158200
- Yonsei Med J.
- 2008 Oct;49(5):811-818.
- doi: 10.3349/ymj.2008.49.5.811
PURPOSE: We have used a genetically attenuated adenoviral vector which expresses HSVtk to assess the possible additive role of suicidal gene therapy for enhanced oncolytic effect of the virus. Expression... -
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- Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
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Cho HS, Lee HR, Kim MK
- KMID: 1785703
- J Korean Med Sci.
- 2004 Feb;19(1):107-112.
- doi: 10.3346/jkms.2004.19.1.107
Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We investigated the bystander effect of retrovirusmediated gene transfer of herpes simplex virus thymidine... -
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