- Significance of thymidine kinase activity in the gastrointestinal cancers
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Roh SK, Chung YW, Kim JH, Lee SJ, Kwun KB
- KMID: 1742121
- J Korean Cancer Assoc.
- 1991 Jun;23(2):230-236.
No abstract available. -
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- Increased Thymidine Kinase Activity and in vitro Bystander Effect by Double Transfer of HSVtk Gene into T98G Tumor Cells
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Kim YG
- KMID: 2188358
- J Korean Neurosurg Soc.
- 1999 Mar;28(3):293-299.
Transduction of retroviral-mediated herpes simplex virus thymidine kinase(HSVtk) gene into tumor cells and subsequent ganciclovir(GCV) treatment have been used as an experimental and clinical therapeutic strategy. Because non-transduced tumor cells... -
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- Nuclear Imaging of Cellular Proliferation
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Yeo JS
- KMID: 2078813
- Korean J Nucl Med.
- 2004 Apr;38(2):198-204.
Tumor cell proliferation is considered to be a useful prognostic indicator of tumor aggressiveness and tumor response to therapy, but in vitro measurement of individual proliferation is complex and tedious... -
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- Cloning, Sequencing and Expression in Escherichia coli of Herpes simple virus Type-1 Thymidine Kinase Gene
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Lee HB, Kim JW, Kang H, Cha SC
- KMID: 1551987
- J Korean Soc Virol.
- 1998 Sep;28(3):215-224.
Cloning, sequencing and expressing in E. coli of the thymidine kinase (TK) gene of Herpes simplex virus type-1 (HSV-1) strain F was investigated. The TK gene, located in the BamHI... -
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- Tumor targeted gene therapy
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Kang JH
- KMID: 1512522
- Nucl Med Mol Imaging.
- 2006 Oct;40(5):237-242.
Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic... -
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- Adenovirus-Mediated Thymidine Kinase Gene Transfer with Exposure of Ganciclovir to Uterine Cervical Cancer Cells
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Kim TE, Ro DY, Kim YW, Kim HK, Lee HS, Jung JK, Kim JW, Namkoong S
- KMID: 2143465
- Korean J Gynecol Oncol Colposc.
- 2003 Sep;14(3):195-201.
OBJECTIVE: Although herpes simplex virus thymidine kinase gene (HSVtk) transfer with ganciclovir (GCV) represents the commonly used suicide gene therapy of human cancers, little is known about the feasibility of... -
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- Usefulness of Serum Thymidine Kinase 1 as a Biomarker for Aggressive Clinical Behavior in B-cell Lymphoma
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Kim H, Kang HJ, Lee JK, Hong YJ, Hong SI, Chang YH
- KMID: 2312288
- Lab Med Online.
- 2016 Jan;6(1):25-30.
- doi: 10.3343/lmo.2016.6.1.25
BACKGROUND: The cell cycle-dependent enzyme thymidine kinase 1 (TK1) is known to increase during cancer cell proliferation and has been reported as a prognostic marker for various hematologic malignancies and... -
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- Effect of Ganciclovir on Growth of Neuroblastoma Cell Line Expressed HSV-TK Gene
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Cho HS, Lyu CJ, Yang CH, Oh SH, Kim KH, Kim KY, Kim BS
- KMID: 2072459
- Korean J Pediatr Hematol Oncol.
- 1997 Apr;4(1):98-104.
BACKGROUND: Replication of defective adenoviral vectors can be used for gene transfer into a wide spectrum of replicating and nonreplicating cells. Accordingly, selective introduction of genes encoding for susceptibility to... -
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- Antitunor effect of carcinoma cells transduced with herpes simplex virus - thymidine kinase by gancyclovir and radiation
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Lee JW, Oh ST, Ahn CH, Lim KW, Cho HI, Kim GR, Kim TG
- KMID: 2150556
- Immune Netw.
- 2001 Apr;1(1):45-52.
- doi: 10.4110/in.2001.1.1.45
BACKGROUND: Many types of cancer become resistant to current chemotherapeutic and radiotherapeutic intervention. To overcome this situation application of gene therapy by the introduction of suicide genes followed by their... -
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- Combination Gene Therapy of Herpes Simplex Virus Thymidine Kinase and Cytokines in Lung Cancer
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Kim G, Park KH, Seol JY, Yoo CG, Lee CT, Kim YW, Han SK, Shim YS
- KMID: 2318345
- Tuberc Respir Dis.
- 2001 Aug;51(2):135-146.
- doi: 10.4046/trd.2001.51.2.135
BACKGROUND: One of the important mechanisms responsible for a tumor escaping the immune response is an absence of the tumor associated antigen (TAA) on the cancer cell surface. To overcome... -
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- Enhanced in vitro and in vivo Bystander Effect by Double Transfer of Herpes Simplex Virus Thymidine Kinase Gene
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Kim YG, Kim ST, Yoon HD
- KMID: 2188505
- J Korean Neurosurg Soc.
- 1999 Oct;28(10):1407-1417.
OBJECTIVE: The bystander effect, the phenomenon that non-transduced tumor cells can be killed along with the transduced cells, enables suicidal gene therapy feasible in spite of low efficiency of gene... -
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- In Vitro Uptakes of Radiolabeled IVDU and IVFRU in Herpes Simplex Virus Type-1 Thymidine Kinase (HSV1-tk) Gene Transduced Morris Hepatoma Cell Line
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Lee TS, Choi TH, Ahn SH, Woo KS, Jeong WS, Kwon HC, Awh OD, Choi CW, Lim SM
- KMID: 1590228
- Korean J Nucl Med.
- 2004 Feb;38(1):62-73.
PURPOSE: The herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) is an attractive candidate as a reporter gene in noninvasive reporter gene monitoring system. The HSV1-tk gene was chosen... -
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- Effects of Integrin avB5 and av B53 on the Adenovirus - Mediated Gene Transduction
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Park JY, Joo SY, Jeon HS, Chang HJ, Kam S, Kim IS
- KMID: 2175115
- J Korean Cancer Assoc.
- 2000 Apr;32(2):422-430.
PURPOSE: Human adenovirus, commonly used as a vector for gene therapy, enters host cells by receptor mediated endocytosis. Since integrin av B5 of cell surface promotes endocytosis of adenovirus and subsequent disruption... -
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- Adenovirus-mediated Suicide Gene Therapy for Experimental Prostate Cancers with in Vivo Tumor Transduction Using the Herpes Simplex Virus Thymidine Kinase Gene/Acyclovir System
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Kim TH, Cheon J, Koh SK
- KMID: 2290369
- Korean J Urol.
- 1999 Aug;40(8):985-991.
PURPOSE: The goal of this in vivo study is to determine the feasibility and efficacy of suicide gene therapy using adenovirus-mediated herpes simplex virus thymidine kinase (HSV-TK) and the prodrug... -
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- Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Therapy for the Prevention of Stenosis in Rat Carotid Artery Injury Model
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Kim DW, Kim YG, Oh TG, Cho MC, Kim ST
- KMID: 2228899
- Korean Circ J.
- 1998 Jun;28(6):977-989.
- doi: 10.4070/kcj.1998.28.6.977
BACKGROUND: Herpes simplex virus thymidine kinase (HSVtk) phosphorylates the prodrug ganciclovir to a nucleoside analog that inhibits DNA synthesis, causing cell death. Neighbouring nontransfected cells may be affected through a... -
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- Effects of Herpes Simplex Virus - Thymidine Kinase Gene Transduction into the Hepatocellular Carcinoma Cell Lines Using the Retrovirus on Ganciclovir Cytoxicity
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Kim JH, Song JJ, Chang YS, Kim EH, Kim JS, Lee HR, Roh JK, Kim BS, Ahn JB, Yoo NC, Chung HC
- KMID: 2175347
- J Korean Cancer Assoc.
- 1998 Oct;30(5):1034-1043.
PURPOSE: Hepatocellular carcinoma (HCC) is one of the most common malignancy with high mortality in Korea. A new therapeutic modality such as gene therapy is necessary to improve the prognosis... -
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- Imaging of Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression with Radiolabeled 5-(2-iodovinyl)-2'-deoxyuridine (IVDU) in Liver by Hydrodynamic-based Procedure
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Song I, Lee TS, Kang JH, Lee YJ, Kim KI, An GI, Chung WS, Cheon GJ, Choi CW, Lim SM
- KMID: 1841152
- Nucl Med Mol Imaging.
- 2009 Oct;43(5):468-477.
PURPOSE: Hydrodynamic-based procedure is a simple and effective gene delivery method to lead a high gene expression in liver tissue. Non-invasive imaging reporter gene system has been used widely with... -
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- Increased Anti-tumor Effect by a Combination of HSV Thymidine Kinase Suicide Gene Therapy and Interferon-gamma/GM-CSF Cytokine Gene Therapy in CT26 Tumor Model
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Yang SH, Oh TK, Kim ST
- KMID: 2157739
- J Korean Med Sci.
- 2005 Dec;20(6):932-937.
- doi: 10.3346/jkms.2005.20.6.932
The potential therapeutic benefit of introducing IFN-gamma and GM-CSF genes in combination with the HSVtk suicide gene into subcutaneously implanted CT26 tumor cells was compared with that from each treatment... -
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- Effect of Immune System on Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Therapy
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Park JY, Joo S, Chang HJ, Son JW, Kim KY, Kim KS, Kim CH, Park JH, Lee JK, Jung TH
- KMID: 2009796
- Tuberc Respir Dis.
- 1999 Feb;46(2):229-240.
- doi: 10.4046/trd.1999.46.2.229
BACKGROUND: The impact of the immune response on cancer gene therapy using viral vectors to deliver a "suicide gene" is currently unclear. A vigrous immune response targeted at viral proteins... -
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- Gene Transfer Effects of Thymidine Kinase Gene of Herpes Simplex Type 1 on Ganciclovir Cytotoxicity in Gastric Cancer Cell Line
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Roh JK, Gong SJ, Kim JH, Um HD, Yoo NC, Choi JH, Song JJ, Rha SY, Chung HC, Min JS, Kim BS
- KMID: 2175424
- J Korean Cancer Assoc.
- 1998 Feb;30(1):20-30.
PURPOSE: Gastric cancer is the most common malignancy in Korea. Although treatment such as surgery, chemotherapy, and immunotherapy has greatly improved, the mortality rate of gastic cancer is... -
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