- Association of serum levels of vascular endothelial growth factor and thrombospondin-1 to body mass index in polycystic ovary syndrome: a case-control study
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Tahergorabi Z, Salmani F, Jonaidabad SH, Behdani B, Yazdi P, Zardast M, Moodi M
- KMID: 2462120
- Obstet Gynecol Sci.
- 2019 Nov;62(6):420-428.
- doi: 10.5468/ogs.2019.62.6.420
PURPOSE: Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarian blood flow and angiogenesis. The aim of this study was to determine the... -
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- Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2
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Kang JH, Kim HJ, Park MK, Lee CH
- KMID: 2395812
- Biomol Ther.
- 2017 Nov;25(6):625-633.
- doi: 10.4062/biomolther.2016.228
Sphingosylphosphorylcholine (SPC) is one of the bioactive phospholipids that has many cellular functions such as cell migration, adhesion, proliferation, angiogenesis, and Ca²⺠signaling. Recent studies have reported that SPC induces... -
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- Inhibition of Angiogenesis by the First Type I Repeat Peptides of Thrombospondin-1
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Yoo BI, Jeong GB
- KMID: 2150440
- Korean J Phys Anthropol.
- 2015 Dec;28(4):223-238.
- doi: 10.11637/kjpa.2015.28.4.223
Angiogenesis is the fundamental biological phenomenon in the development of vertebrates and various pathophysiological process such as cancer, inflammation and wound healing. Thrombospondin-1 is a well-known anti-angiogenic molecule which is... -
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- Thrombospondin-1 and Inhibition of Tumor Growth
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Jeong GB
- KMID: 2150435
- Korean J Phys Anthropol.
- 2015 Dec;28(4):175-184.
- doi: 10.11637/kjpa.2015.28.4.175
Thrmobospondin-1 is the multifunctional protein that modulates endothelial cell and tumor cell behavior via several cell surface receptors and inhibits angiogenesis. In vitro, thrombospondin-1 alters adhesion, proliferation, motility, and survival... -
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- Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus
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Choi KY, Kim DB, Kim MJ, Kwon BJ, Chang SY, Jang SW, Cho EJ, Rho TH, Kim JH
- KMID: 1826381
- Korean Circ J.
- 2012 Feb;42(2):100-106.
- doi: 10.4070/kcj.2012.42.2.100
BACKGROUND AND OBJECTIVES: Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated... -
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- Loss of Heterozygosity on Chromosome 15q15 Near Thrombospondin-1 Gene in Breast Carcinomas
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Kim J, Kim KM, Lee H, Lee K, Rhyu MG, Lee A, Kang SJ, Lee KY
- KMID: 1979339
- Korean J Pathol.
- 2009 Jun;43(3):221-230.
BACKGROUND: Chromosome 15q15 near the thrombospondin-1 (THBS-1) gene may be associated with tumor progression and metastasis. To clarify the potential role of the15q15 region in progression of breast carcinoma, we... -
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- Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 mRNA Related to Microvessel Density in Invasive Cervical Carcinomas
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Lee JE, Lee SK, Chi SG
- KMID: 2272998
- Korean J Obstet Gynecol.
- 2006 Dec;49(12):2573-2582.
OBJECTIVE: Vascular Endothelial Growth Factor (VEGF) is a potent stimulator of angiogenesis in solid tumors. Thrombospondin-1 (TSP-1) has inhibitory role in cancer cell proliferation and metastasis. To analyze the correlation... -
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- The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells
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Ryu GR, Kang JH, Hong KJ, Jeong IK, Jang HI, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH, Kim MJ
- KMID: 2200845
- J Korean Soc Endocrinol.
- 2006 Aug;21(4):302-310.
- doi: 10.3803/jkes.2006.21.4.302
BACKGROUND: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascular complications such as atherosclerosis.... -
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- TSP-1 mRNA Expression in Invasive Cervical Cancer: Correlate with Angiogenesis and Clinicopathological Features
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Kim YH, Lee SK, Chi SG, Lee JH, Kim SB
- KMID: 2272188
- Korean J Obstet Gynecol.
- 2003 Nov;46(11):2170-2179.
OBJECTIVE: Acquisition of a proangiogenic environment is essential to the cervical cancer growth, invasion and metastasis, and the angiogenic phenotype in cervical cancer is strongly associated with clinical outcome. However,... -
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- Expressions of Thrombospondin-1 and Vascular Endothelial Growth Factor and Their Relationship with p53 Status in Prostate Cancer and Benign Prostatic Hyperplasia
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Kim C, Baek MK, Kim TH, Jeong H, Byun SS, Jeon YK, Kwak C, Kang GH, Lee SE
- KMID: 2292640
- Korean J Urol.
- 2002 Jul;43(7):591-597.
PURPOSE: The precise role of angiogenesis in prostate cancer should be defined. Several reports suggest that thrombospondin-1 (TSP-1) possesses a tumor suppressor function, possibly through its ability to inhibit tumor... -
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- The Effect of Endocrine Therapy on Angiogenesis and the Expression of Thrombospondin-1 and Vascular Endothelial Growth Factor in Prostate Cancer
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Kwak C, Jeong H, Byun SS, Baek M, Kim C, Kim T, Lee SE
- KMID: 2292617
- Korean J Urol.
- 2002 May;43(5):372-379.
PURPOSE: The exact role of angiogenesis in prostate cancer is unknown. We investigated whether endocrine therapy inhibits angiogenesis, and influences the expression of thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis,... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Observation of Endothelial Cell Differentiation by 3D Cell culture system: Angiogenesis inhibition of Thrombospondin-1
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Jeong GB, Baik SH, Frazier WA
- KMID: 1530487
- Korean J Anat.
- 1999 Jun;32(3):293-304.
Angiogenesis plays a fundamental role in development of circulation system, reorganization of reproductive system, wound healing. Pathological angiogenesis is deeply involved in a variety of diseases, particularly solid tumor growth... -
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