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Immunosuppressive Drug Measurement by Liquid Chromatography Coupled to Tandem Mass Spectrometry: Interlaboratory Comparison in the Korean Clinical Laboratories

Kim HK, Park HD, Lee SG, Chae H, Song SH, Lee YW, Yun YM, Ahn S, Kim S, Lee SM, Lee SY, Chun S, on behalf of the Clinical Mass Spectrometry Research Committee of the Korean Society of Clinical Chemistry

Background: Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is increasingly used for immunosuppressive drug tests. However, most LC-MS/MS tests are laboratory-developed and their agreement is unknown in different Korean...
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Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia

Choi R, Chun MR, Park J, Lee JW, Ju HY, Cho HW, Hyun JK, Koo HH, Yi ES, Lee SY

Background: We developed an assay to measure DNA-incorporated 6-thioguanine (DNATG) and validated its clinical applicability in Korean pediatric patients with acute lymphoblastic leukemia (ALL) in order to improve individualized thiopurine...
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Potential Utility of Therapeutic DrugMonitoring of Adalimumab in Predicting Short-Term Mucosal Healing and Histologic Remission in Pediatric Crohn's Disease Patients

Choi SY, Choi YO, Choe YH, Kang B

Background: Limited data exist regarding mucosal healing (MH) and therapeutic drug monitoring (TDM) in pediatric Crohn's disease (CD) patients treated with adalimumab (ADL). We aimed to investigate the associations between...
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Plasma Risperidone-related Measures in Children and Adolescents with Oppositional Defiant/Conduct Disorders

Piacentino D, Kotzalidis GD, Schoretsanitis G, Paulzen M, Haen E, Cappelletti S, Giupponi G, Grözinger M, Conca A

Objective: Therapeutic drug monitoring helps clinicians in choosing the right drug and adjust its dose in specific patients. To this end, we aimed to assess time patterns of risperidone and...
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Report of the Korean Association of External Quality Assessment Service on Therapeutic Drug Monitoring and Toxicology (2015–2019)

Kim HK, Ko DH, Jeong TD, Shin ES, Kim JH, Chun S

Korean Association of External Quality Assessment Service offered to conduct a proficiency test program for therapeutic drug monitoring (TDM) and testing drugs of abuse (DOA), which was named as the...
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Vancomycin and Aminoglycoside Antibiotic Drug Concentration Measurement: Current Status in Clinical Laboratories in Korea

Kwon WK, Oh J, Lee SY, Park HD

Background: Therapeutic drug monitoring (TDM) is clinically recommended for vancomycin and aminoglycoside antibiotics owing to their narrow therapeutic range and nephrotoxicity at high concentrations in the blood. This study was...
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Validation of Voriconazole Therapeutic Drug Monitoring in Lung Transplant Recipients Receiving Voriconazole alone for Treatment of Invasive Aspergillosis

Son YJ, Lee KA, Jo JH, Kim JS, Son ES, Park MS

BACKGROUND: Invasive aspergillosis (IA) is associated with high morbidity and mortality, particularly among immunocompromised patients, such as lung transplant recipients. Voriconazole, the first-line therapy for IA, shows a non-linear pharmacokinetic...
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Multi-center Performance Evaluations of Tacrolimus and Cyclosporine Electrochemiluminescence Immunoassays in the Asia-Pacific Region

Qin X, Rui J, Xia Y, Mu H, Song SH, Raja Aziddin RE, Miles G, Sun Y, Chun S

BACKGROUND: The immunosuppressant drugs (ISDs), tacrolimus and cyclosporine, are vital for solid organ transplant patients to prevent rejection. However, toxicity is a concern, and absorption is highly variable across patients;...
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Pharmacodynamic principles and target concentration intervention

Holford N

This tutorial reviews the principles of dose individualisation with an emphasis on target concentration intervention (TCI). Once a target effect is chosen then pharmacodynamics can predict the target concentration and...
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Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations

Choi R, Jeong BH, Koh WJ, Lee SY

Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the...
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Multiplex Assay of Second-Line Anti-Tuberculosis Drugs in Dried Blood Spots Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Lee K, Jun SH, Han M, Song SH, Park JS, Lee JH, Park KU, Song J

As dried blood spots (DBSs) have various advantages over conventional venous blood sampling, some assays for detection of one or two anti-tuberculosis (TB) drugs in DBSs have been developed. However,...
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Therapeutic drug monitoring of vancomycin in a patient with Duchenne muscular dystrophy (DMD): A case report

Lee SW, Yoon S, Yu KS, Lee S

Vancomycin is a widely used glycopeptide antibiotic that requires therapeutic drug monitoring (TDM) owing to its narrow therapeutic window. It is primarily eliminated by renal excretion; thus, estimating the renal...
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Drug-induced Hepatotoxicity of Anti-tuberculosis Drugs and Their Serum Levels

Jeong I, Park JS, Cho YJ, Yoon HI, Song J, Lee CT, Lee JH

The correlation between serum anti-tuberculosis (TB) drug levels and the drug-induced hepatotoxicity (DIH) remains unclear. The purpose of this study was to investigate whether anti-TB DIH is associated with basal...
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Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation

Kim H, Yi NJ, Lee J, Kim J, Moon MR, Jeong J, Lee JM, You TS, Suh SW, Park MS, Choi Y, Hong G, Lee HW, Lee KW, Suh KS

BACKGROUND/AIMS: The dose of mycophenolate mofetil (MMF) has been reduced in Asia due to side effects associated with the conventional fixed dose of 2-3 g/day. We aimed to determine the...
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Voriconazole Therapeutic Drug Monitoring is Necessary for Children with Invasive Fungal Infection

Kang HM, Kang SY, Cho EY, Yu KS, Lee JW, Kang HJ, Park KD, Shin HY, Ahn HS, Lee H, Choi EH, Lee HJ

  • KMID: 1705182
  • Korean J Pediatr Infect Dis.
  • 2014 Apr;21(1):9-21.
PURPOSE: To determine the clinical significance of voriconazole therapeutic drug monitoring (TDM) in the pediatric population. METHODS: Twenty-eight patients with invasive fungal infections administered with voriconazole from July 2010 to June...
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Performance Evaluation of the Syva EMIT Methotrexate Assay on the Toshiba 200FR NEO

Lim J, Kim J, Sohn YH, Koo SH, Kwon GC

BACKGROUND: Methotrexate (MTX) is an antifolate antagonist that is widely used for treating various malignancies and non-malignant diseases. MTX levels should be monitored when used in high concentration to determine...
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Assessment of Therapeutic Drug Monitoring of Vancomycin in Elderly Patients According to New Guidelines

Oh SJ, Hong KS, Lee EJ, Choi HJ, Kong KA, Lee M, Chung WS

BACKGROUND: Concerns regarding increasing microbial resistance to vancomycin have resulted in recommendations for a higher trough serum vancomycin concentration. This study aimed to assess the dosage guidelines targeting vancomycin trough...
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Therapeutic Drug Monitoring of Topiramate in Status Epilepticus

Koo DL, Seo S, Kim D, Hong SB, Joo EY, Lee SY

  • KMID: 1431577
  • J Korean Epilepsy Soc.
  • 2013 Jun;17(1):1-7.
PURPOSE: Status epilepticus (SE) is a pathologic state where pharmacokinetic alterations can be more pronounced and more rapid than during the other epileptic states. The consequences of such changes can...
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Clinical Impact of Cytochrome P450 2C19 Genotype on the Treatment of Invasive Aspergillosis under Routine Therapeutic Drug Monitoring of Voriconazole in a Korean Population

Kim SH, Lee DG, Kwon JC, Lee HJ, Cho SY, Park C, Kwon EY, Park SH, Choi SM, Choi JH, Yoo JH

BACKGROUND: Genetic polymorphisms of cytochrome P450 enzymes, especially CYP2C19 influence voriconazole pharmacokinetics. However, the impact of CYP2C19 genetic polymorphisms on the therapeutic efficacy and toxicity of voriconazole therapy are not...
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Antimicrobial Management of Neonatal Sepsis

Kim EA

Neonatal infections are frequent complications of neonates receiving intensive care unit. In particular, large cohort study has suggested that neonatal infections among extremely low birth weight infants are associated with...
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