- Corrigendum to: Protective effects of lutein against vancomycininduced acute renal injury in mice via upregulation of peroxisome proliferator-activated receptor gamma/nuclear factor erythroid 2-related factor 2 and inhibition of nuclear factor-kappaB/ caspase 3
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Emeka PM, Rasool ST, Morsy MA, Hairul Islam MI, Chohan MS
- KMID: 2519412
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):495.
- doi: 10.4196/kjpp.2021.25.5.495
No abstract available -
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- Loss of RAR-α and RXR-α and enhanced caspase-3-dependent apoptosis in N-acetyl-p-aminophenol-induced liver injury in mice is tissue factor dependent
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Abdel-Bakky MS, Helal GK, El-Sayed ESM, Amin E, Alqasoumi A, Alhowail A, Said Abdelmoti ES, Saad AS
- KMID: 2519401
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):385-393.
- doi: 10.4196/kjpp.2021.25.5.385
Tissue factor (TF) activates the coagulation system and has an important role in the pathogenesis of various diseases. Our previous study stated that retinoid receptors (RAR-α and RXR-α) are released... -
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- Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy
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Bae Y, Lee J, Kho C, Choi JS, Han J
- KMID: 2519409
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):467-478.
- doi: 10.4196/kjpp.2021.25.5.467
In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering... -
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- Dronedarone hydrochloride enhances the bioactivity of endothelial progenitor cells via regulation of the AKT signaling pathway
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Zhang J, Van Le TH, Rethineswaran VK, Kim YJ, Jang WB, Ji ST, Giang Ly TT, Ha JS, Yun J, Cheong JH, Jung J, Kwon SM
- KMID: 2519408
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):459-466.
- doi: 10.4196/kjpp.2021.25.5.459
Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell... -
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- 5-HT 1A receptors mediate the analgesic effect of rosavin in a mouse model of oxaliplatin-induced peripheral neuropathic pain
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Li D, Park S, Lee K, Jang DS, Kim SK
- KMID: 2519411
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):489-494.
- doi: 10.4196/kjpp.2021.25.5.489
Oxaliplatin, a third-generation platinum derivative, is the mainstay of current antineoplastic medications for advanced colorectal cancer therapy. However, peripheral neuropathic complications, especially cold allodynia, undermine the lifeprolonging outcome of this... -
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- Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats
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Yang HJ, Kim MJ, Kim SS, Cho YW
- KMID: 2519407
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):449-457.
- doi: 10.4196/kjpp.2021.25.5.449
The sleep-wake cycle is regulated by the alternating activity of sleep- and wake-promoting neurons. The dorsal raphe nucleus (DRN) secretes 5-hydroxytryptamine (5-HT, serotonin), promoting wakefulness. Melatonin secreted from the pineal... -
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- Anti-inflammatory effects of DA-9601, an extract of Artemisia asiatica, on aceclofenac-induced acute enteritis
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Kim JH, Shin CY, Jang SW, Kim DS, Lee W, Kim HG, Kim HR
- KMID: 2519406
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):439-448.
- doi: 10.4196/kjpp.2021.25.5.439
DA-9601 is an extract obtained from Artemisia asiatica, which has been reported to have anti-inflammatory effects on gastrointestinal lesions; however, its possible anti-inflammatory effects on the small intestine have not... -
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- Docetaxel-loaded PLGA nanoparticles to increase pharmacological sensitivity in MDA-MB-231 and MCF-7 breast cancer cells
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Tran P, Nguyen TN, Lee Y, Tran PN, Park JS
- KMID: 2519410
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):479-488.
- doi: 10.4196/kjpp.2021.25.5.479
This study aimed to develop docetaxel (DTX) loaded poly(lactic-coglycolic acid) (PLGA) nanoparticles (DTX-NPs) and to evaluate the different pharmacological sensitivity of NPs to MCF-7 and MDA-MB-231 breast cancer cells. NPs... -
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- Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation
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Yang L, Chen X, Bi Z, Liao J, Zhao W, Huang W
- KMID: 2519404
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):413-423.
- doi: 10.4196/kjpp.2021.25.5.413
Apoptosis is proved responsible for renal damage during ischemia/reperfusion. The regulation for renal apoptosis induced by ischemia/reperfusion injury (IRI) has still been unclearly characterized to date. In the present study,... -
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- Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages
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Yin L, Shi C, Zhang Z, Wang W, Li M
- KMID: 2519402
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):395-401.
- doi: 10.4196/kjpp.2021.25.5.395
Extended inflammation and cytokine production pathogenically contribute to a number of inflammatory disorders. Formosanin C (FC) is the major diosgenin saponin found in herb Paris formosana Hayata (Liliaceae), which has... -
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- Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect
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Chang XM, Xiao F, Pan Q, Wang XX, Guo LX
- KMID: 2519405
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):425-437.
- doi: 10.4196/kjpp.2021.25.5.425
Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Autophagy plays an important role in the development of diabetes mellitus, but... -
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- Gastroprotective effect of cirsilineol against hydrochloric acid/ ethanol-induced gastric ulcer in rats
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Gong G, Zhao R, Zhu Y, Yu J, Wei B, Xu Y, Cui Z, Liang G
- KMID: 2519403
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):403-411.
- doi: 10.4196/kjpp.2021.25.5.403
This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced... -
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