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An experience on the model-based evaluation of pharmacokinetic drug-drug interaction for a long half-life drug

Hong Y, Jeon S, Choi S, Han S, Park M, Han S

Fixed-dose combinations development requires pharmacokinetic drugdrug interaction (DDI) studies between active ingredients. For some drugs, pharmacokinetic properties such as long half-life or delayed distribution, make it difficult to conduct such...
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Aging effects on the diurnal patterns of gut microbial composition in male and female mice

Kim HJ, Moon CM, Kang JL, Park EM

Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the...
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Roles for α1-adrenoceptors during contractions by electrical field stimulation in mouse vas deferens

Alsufyani HA, Docherty JR

We have investigated the relative roles of α1-adrenoceptors and purinoceptors in contractions to low and high frequency stimulation of the mouse vas deferens, in terms of the time course of...
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Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl 2 negatively regulates neurosphere formation in culture

Kwon JK, Choi DJ, Yang H, Ko DW, Jou I, Park SM, Joe EH

Astrocytes are activated in response to brain damage. Here, we found that expression of Kir4.1, a major potassium channel in astrocytes, is increased in activated astrocytes in the injured brain...
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Influences of ethanol and temperature on sucrose-evoked response of gustatory neurons in the hamster solitary nucleus

Li CS, Chung KM, Kim KN, Cho YK

Taste-responsive neurons in the nucleus of the solitary tract (NST), the first gustatory nucleus, often respond to thermal or mechanical stimulation. Alcohol, not a typical taste modality, is a rewarding...
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Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole

Kim GM, Sohn HJ, Choi WS, Sohn UD

Postoperative ileus (POI), a symptom that occurs after abdominal surgery, reduces gastrointestinal motility. Although its mechanism is unclear, POI symptoms are known to be caused by inflammation 6 to 72...
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Effects of exercise on AKT/PGC1-α/FOXO3a pathway and muscle atrophy in cisplatin-administered rat skeletal muscle

Bae JH, Seo DY, Lee SH, Shin C, Jamrasi P, Han J, Song W

Cisplatin has been reported to cause side effects such as muscle wasting in humans and rodents. The physiological mechanisms involved in preventing muscle wasting, such as the regulation of AKT,...
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Triptolide improves myocardial fibrosis in rats through inhibition of nuclear factor kappa B and NLR family pyrin domain containing 3 inflammasome pathway

Shen J, Ma H, Wang C

Myocardial fibrosis (MF) is the result of persistent and repeated aggravation of myocardial ischemia and hypoxia, leading to the gradual development of heart failure of chronic ischemic heart disease. Triptolide...
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Beneficial effects of naringenin and morin on interleukin-5 and reactive oxygen species production in BALB/c mice with ovalbumin-induced asthma

Qi P, Wei C, Kou D

We investigated the effects of naringenin and morin on IL-5 and ROS production in PMA+ionomycin-treated EL-4 cells with the corroboration of their antioxidant and anti-inflammatory properties using an asthma-induced mouse...
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Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia

Zhao C, Guo Y, Wang R, Cheng C, Chen X

The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. Thirty Sprague–Dawley rats were randomly divided into five...
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Depilatory creams increase the number of hair follicles, and dermal fibroblasts expressing interleukin-6, tumor necrosis factor-α, and tumor necrosis factor-β in mouse skin

Tsai PF, Chou FP, Yu TS, Lee HJ, Chiu CT

Besides using for hair removal, depilatory agents have been considered to be used as a penetration enhancer for transepidermal drug delivery. To examine the effect in hair follicles (HFs), two...
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Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase

Han SJ, Kim JI, Lipschutz JH, Park KM

Primary cilia on kidney tubular cells play crucial roles in maintaining structure and physiological function. Emerging evidence indicates that the absence of primary cilia, and their length, are associated with...
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