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The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

Lee HY, Nam Y, Choi WS, Kim TW, Lee J, Sohn UD

Eupatilin is known to possess anti-apoptotic, anti-oxidative, and antiinflammatoryproperties. We report here that eupatilin has a protective effect onthe ethanol-induced injury in rats. Sprague–Dawley rats were divided into 6 groups:control,...
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Inhibitory actions of borneol on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice

Nguyen PTT, Jang SH, Rijal S, Park SJ, Han SK

The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis(Vc) is the first relay site for the orofacial nociceptive inputs via the thin myelinatedAδ and unmyelinated C primary afferent fibers. Borneol,...
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Delphinidin enhances radio-therapeutic effects via autophagyinduction and JNK/MAPK pathway activation in non-small celllung cancer

Kang SH, Bak DH, Chung BY, Bai HW, Kang BS

Delphinidin is a major anthocyanidin compound found in various vegetablesand fruits. It has anti-oxidant, anti-inflammatory, and various other biologicalactivities. In this study we demonstrated the anti-cancer activity of delphinidin,which was...
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Four active monomers from Moutan Cortex exert inhibitoryeffects against oxidative stress by activating Nrf2/Keap1signaling pathway

Zhang B, Yu D, Luo N, Yang C, Zhu Y

Paeonol, quercetin, -sitosterol, and gallic acid extracted from MoutanCortex had been reported to possess anti-oxidative, anti-inflammatory, and antitumoractivities. This work aimed to illustrate the potential anti-oxidative mechanismof monomers in human...
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Curcumin targets vascular endothelial growth factor viaactivating the PI3K/Akt signaling pathway and improves brainhypoxic-ischemic injury in neonatal rats

Li J, An Y, Wang JN, Yin XP, Zhou H, Wang YS

This study aimed to evaluate the effect of curcumin on brain hypoxicischemic(HI) damage in neonatal rats and whether the phosphoinositide 3-kinase(PI3K)/Akt/vascular endothelial growth factor (VEGF) signaling pathway is involved.Brain HI...
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Effects of troxerutin on vascular inflammatory mediators andexpression of microRNA-146a/NF-B signaling pathway in aortaof healthy and diabetic rats

Xing C, Xiang D, Caiying L

This study has investigated the effect of a potent bioflavonoid, troxerutin,on diabetes-induced changes in pro-inflammatory mediators and expression ofmicroRNA-146a and nuclear factor-kappa-B (NF-κB) signaling pathway in aortic tissueof type-I diabetic...
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Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose- induced apoptosis

Chian CW, Lee YS, Lee YJ, Chen YH, Wang CP, Lee WC, Lee HJ

Diabetic nephropathy (DN) is a hyperglycemia-induced progressivedevelopment of renal insufficiency. Excessive glucose can increase mitochondrialreactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction.Our previous study indicated that cilostazol...
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