- Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse
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Park SH, Sim YB, Kang YJ, Lee JK, Lim SS, Suh HW
- KMID: 2071757
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):119-123.
- doi: 10.4196/kjpp.2012.16.2.119
In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as... -
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- Standard Error of Empirical Bayes Estimate in NONMEM(R) VI
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Kang D, Bae KS, Houk BE, Savic RM, Karlsson M
- KMID: 2071754
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):97-106.
- doi: 10.4196/kjpp.2012.16.2.97
The pharmacokinetics/pharmacodynamics analysis software NONMEM(R) output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple... -
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- Pretreatment of Albino Rats with Methanolic Fruit Extract of Randia Dumetorum (L.) Protects against Alcohol Induced Liver Damage
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Noorani AA, Kale MK
- KMID: 2071758
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):125-130.
- doi: 10.4196/kjpp.2012.16.2.125
Alcohol abuse and its medical and social consequences are a major health problem in many areas of the world. The present study was conducted to evaluate the protective effect of... -
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- TRPC-Mediated Current Is Not Involved in Endocannabinoid-Induced Short-Term Depression in Cerebellum
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Chang W, Park JM, Kim J, Kim SJ
- KMID: 2071760
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):139-144.
- doi: 10.4196/kjpp.2012.16.2.139
It has been reported that activation of metabotropic glutamate receptor 1 (mGluR1) can mediate endocannabinoid-induced short-term depression of synaptic transmission in cerebellar parallel fiber (PF)-Purkinje cell (PC) synapse. mGluR1 has... -
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- Altered Regulation of Renal Acid Base Transporters in Response to Ammonium Chloride Loading in Rats
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Kim EY, Choi JS, Lee KE, Kim CS, Bae EH, Ma SK, Kim SH, Lee JU, Kim SW
- KMID: 2071753
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):91-95.
- doi: 10.4196/kjpp.2012.16.2.91
The role of the kidney in combating metabolic acidosis has been a subject of considerable interest for many years. The present study was aimed to determine whether there is an... -
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- Effects of Protopanaxatriol-Ginsenoside Metabolites on Rat N-Methyl-D-Aspartic Acid Receptor-Mediated Ion Currents
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Shin TJ, Hwang SH, Choi SH, Lee BH, Kang J, Kim HJ, Zukin RS, Rhim H, Nah SY
- KMID: 2071756
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):113-118.
- doi: 10.4196/kjpp.2012.16.2.113
Ginsenosides are low molecular weight glycosides found in ginseng that exhibit neuroprotective effects through inhibition of N-methyl-D-aspartic acid (NMDA) receptor channel activity. Ginsenosides, like other natural compounds, are metabolized by... -
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- Cilostazol Decreases Ethanol-Mediated TNFalpha Expression in RAW264.7 Murine Macrophage and in Liver from Binge Drinking Mice
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Lee YJ, Eun JR
- KMID: 2071759
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):131-138.
- doi: 10.4196/kjpp.2012.16.2.131
Alcoholic hepatitis is a leading cause of liver failure in which the increased production of tumor necrosis factor alpha (TNFalpha) plays a critical role in progression of alcoholic liver disease.... -
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- 3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-kappaB Activation in BV2 Microglial Cells
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Lee JW, Bae CJ, Choi YJ, Kim SI, Kim NH, Lee HJ, Kim SS, Kwon YS, Chun W
- KMID: 2071755
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):107-112.
- doi: 10.4196/kjpp.2012.16.2.107
Although various derivatives of caffeic acid have been reported to possess a wide variety of biological activities such as neuronal protection against excitotoxicity and anti-inflammatory property, the biological activity of... -
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- Differential Effects of Tautomycetin and Its Derivatives on Protein Phosphatase Inhibition, Immunosuppressive Function and Antitumor Activity
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Niu M, Sun Y, Liu B, Tang L, Qiu R
- KMID: 2071761
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):145-151.
- doi: 10.4196/kjpp.2012.16.2.145
In the present work, we studied the structure-activity relationship (SAR) of tautomycetin (TMC) and its derivatives. Further, we demonstrated the correlation between the immunosuppressive fuction, anticancer activity and protein phosphatase... -
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- Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats
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Lee B, Sur B, Shim I, Lee H, Hahm DH
- KMID: 2071752
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):79-89.
- doi: 10.4196/kjpp.2012.16.2.79
We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic... -
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