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Direct Block of Cloned K+ Channels, Kv1.5 and Kv1.3, by Cyclosporin A, Independent of Calcineurin Inhibition

Choi BH, Hahn SJ

  • KMID: 2071619
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):353-361.
The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique....
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Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells

Heo HJ, Lee HJ, Yoon CS, Lim SP, Seok JH, Seo UK, Lee CJ

  • KMID: 2071614
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):323-326.
In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and...
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Gene Transfer of Cu/ZnSOD to Cerebral Vessels Prevents Subarachnoid Hemorrhage-induced Cerebral Vasospasm

Yun MR, Kim DE, Heo HJ, Park JY, Lee JY, Bae SS, Kim CD

  • KMID: 2071615
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):327-332.
The preventive effects of gene transfer of human copper/zinc superoxide dismutase (Cu/ZnSOD) on the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) were examined using a rat model of SAH....
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The Effects of DTBNP on Intracellular Ca2+ Signaling in Cultured Bovine Aortic Endothelial Cells

Park SJ, Kim BJ, Zhu MH, So I, Kim KW

  • KMID: 2071617
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):341-346.
The mechanism underlying oxidant-induced intracellular Ca2+ ([Ca2+]i) increase was studied in cultured bovine aortic endothelial cells (BAECs) using fura-2 AM. In the presence of 2 mM extracellular Ca2+, the application...
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Conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death

Bu MH, Lee KA, Kim KH, Rhim BY

  • KMID: 2071613
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):315-322.
In this study, the authors investigated whether death of vascular smooth muscle cell (VSMC) had a pathological pertinence. Conditioned media obtained from rat aorta smooth muscle cell (SMC) that were...
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Calcium Ion Dynamics after Dexamethasone Treatment in Organotypic Cultured Hippocampal Slice

Chae HJ, Kang TH, Park JH

  • KMID: 2071620
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):363-369.
It is imperative to analyse brain injuries directly in real time, so as to find effective therapeutic compounds to protect brain injuries by stress. We established a system which could...
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Effects of Nitric Oxide on Inhibitory Receptors of Rod Bipolar Cells of Rat Retina

Park NG, Bai SH, Jung CS, Chun MH

  • KMID: 2071618
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):347-352.
The effects of nitric oxide (NO) on inhibitory neurotransmitter receptors and some types of inhibitory receptors in dissociated rod bipolar cell (RBC) were investigated. In the whole cell voltage-clamping mode,...
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PKA-Mediated Regulation of B/K Gene Transcription in PC12 Cells

Choi MH, Kim HS, Choi SH, Kim MY, Jang YS, Jang YM, Lee JH, Jeong SW, Kim IK, Kwon OJ

  • KMID: 2071616
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):333-339.
B/K protein is a novel protein containing double C2-like domains. We examined the specific signaling pathway that regulates the transcription of B/K in PC12 cells. When the cells were treated...
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