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Choi GE, Kang JE, Lee EY, Chang CL, Tateda K, Yamaguchi , Kim KH, Kim JM

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Kim DW, Shin MG, Yun HK, Kim SH, Shin JH, Suh SP, Ryang DW

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A Case of Post-Essential Thrombocythemia Myelofibrosis with Severe Osteosclerosis

Lee KK, Cho HI, Chi HS, Kim DY, Chae SL, Huh HJ

Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage. After many years, a few patients with ET may develop bone marrow (BM) fibrosis and rarely...
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Down-Turner Syndrome (45,X/47,XY,+21): Case Report and Review

Ryu SW, Lee G, Baik CS, Shim SH, Kim JT, Lee JS, Lee KA

We report the case of a 3-yr-old boy with Down-Turner mosaicism and review the previous reports of Down-Turner syndrome with documented karyotyping and clinical features. The patient showed clinical features...
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Relationship between the Levels of Holotranscobalamin and Vitamin B12

Woo KS, Kim KE, Park JS, Park JI, Han JY

To date, the determination of serum vitamin B12 levels has been the most common laboratory test for the assessment of vitamin B12 status; however, the diagnostic accuracy of this test...
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Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature

Huh JY, Chung S, Oh D, Kang MS, Eom HS, Cho EH, Han MH, Kong SY

The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with...
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Immunophenotypic Features of Granulocytes, Monocytes, and Blasts in Myelodysplastic Syndromes

Moon HW, Huh JW, Lee M, Hong KS, Chung WS

BACKGROUND: Despite the diagnostic utility of immunophenotyping for myelodysplastic syndromes (MDS), it has not been widely performed, and reports on this are absent in Korea. We aimed to evaluate the...
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Detection of Vancomycin-resistant Enterococci using Multiplex Real-time PCR Assay and Melting Curve Analysis

Cha CH, An HK, Kim JU

BACKGROUND: We developed and evaluated the utility of a multiplex real-time PCR assay that uses melting curve analysis and allows simultaneous identification of vancomycin-resistant genotypes and clinically relevant enterococci. METHODS: The...
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Clinical Usefulness of T-SPOT.TB Test for the Diagnosis of Tuberculosis

Kim HS, Kim CH, Hur M, Hyun IG, Park MJ, Song W, Park JY, Kang HJ, Lee KM

BACKGROUND: Tuberculosis-specific ELISPOT assay (T-SPOT.TB, Oxford Immunotec, UK) is a test that detects interferon-gamma producing T-cells after stimulating patient's lymphocytes with two kinds of tuberculosis-specific antigens (ESAT-6 and CFP-10). We...
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Evaluation of the Efficacies of Rapid Antigen Test, Multiplex PCR, and Real-time PCR for the Detection of a Novel Influenza A (H1N1) Virus

Hwang Y, Kim K, Lee M

BACKGROUND: In April 2009, a novel influenza A (H1N1) virus was detected in the US, and at the time of conducting this study, H1N1 infection had reached pandemic proportions. In...
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Molecular Analysis of Two Cases of Severe Congenital Neutropenia

Park J, Kim M, Lim J, Kim Y, Cho B, Park YJ, Han K

Severe congenital neutropenia is a rare hematological disease characterized by a selective decrease in circulating neutrophils, maturation arrest of granulocytic precursors at the promyelocyte stage, and recurrence of infections. A...
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Performance Characteristics of the UniCel DxI 800 Immunoassay for the Maternal Serum Quadruple Test, Including Median Values for Each Week of Gestation, in Korean Women

Lee JH, Park Y, Suh B, Song SM, Kwon OH, Kim JH

BACKGROUND: Maternal serum prenatal quadruple screening includes testing for alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated estriol (uE3), and dimeric inhibin A (DIA). We evaluated quadruple screening using an automated...
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Molecular Characterization of the NF2 Gene in Korean Patients with Neurofibromatosis Type 2: A Report of Four Novel Mutations

Seong MW, Yeo IK, Cho SI, Park CK, Kim SK, Paek SH, Kim DG, Jung HW, Park H, Kim SY, Kim JY, Park SS

BACKGROUND: Neurofibromatosis type 2 (NF2) is an autosomal dominant syndrome caused by the NF2 tumor suppressor gene. However, the NF2 mutation characteristics in Korean patients are not sufficiently understood. In...
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Disseminated Mycobacterium avium Complex Infection in a Non-HIV-infected Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

Chung JW, Cha YJ, Oh DJ, Nam WJ, Kim SH, Lee MK, Kim HR

Isolated bone marrow infection by nontuberculous mycobacteria (NTM) is extremely rare. Recently, we encountered a case of bone marrow Mycobacterium avium complex (MAC) infection, which presented as a fever of...
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Evaluation of the Clinical Performance of an Automated Procalcitonin Assay for the Quantitative Detection of Bloodstream Infection

Kim KE, Han JY

BACKGROUND: Bloodstream infection (BSI) is associated with a high mortality rate. Since the origin of infection is demonstrated in approximately 2/3rds of cases, early and established biomarkers are warranted. We...
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A Case of Streptococcus gallolyticus subsp. gallolyticus Infective Endocarditis with Colon Cancer: Identification by 16S Ribosomal DNA Sequencing

Kim SY, Joo SI, Yi J, Kim EC

Although the association between Streptococcus bovis endocarditis and colon carcinoma is well known, very few cases of S. bovis infection associated with underlying malignancies have been reported in Korea. The...
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Comparison of Nine Different Qualitative HBsAg Assay Kits

Yang J, Kim JH, Kim Y

BACKGROUND: Qualitative hepatitis B surface antigen (HBsAg) assay kits are still commonly used in Korea where hepatitis B virus (HBV) infection is endemic. The accurate determination of HBsAg plays a...
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Development and Evaluation of the Quick Anaero-system-A New Disposable Anaerobic Culture System

Yang NW, Kim JM, Choi GJ, Jang SJ

BACKGROUND: We developed a new disposable anaerobic culture system, namely, the Quick anaero-system, for easy culturing of obligate anaerobes. METHODS: Our system consists of 3 components: 1) new disposable anaerobic gas...
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Myelodysplastic Syndrome Mimicking Idiopathic Thrombocytopenic Purpura

Hwang Y, Huh JW, Mun YC, Seong CM, Chung WS

BACKGROUND: In patients with isolated thrombocytopenia, but without significant dysplasia, diagnosis of idiopathic thrombocytopenic purpura (ITP) rather than myelodysplastic syndrome (MDS) may be taken into account. It is important to...
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