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Evaluation of Automated Architect Syphilis TP as a Diagnostic Laboratory Screening Test for Syphilis

Kim J, Kim WH, Cho C, Kim J, Kim GY, Nam MH, Kim JS, Bae SY, Cho Y

BACKGROUND: The aim of the study was to establish a new syphilis test algorithm using Architect Syphilis TP (Abbott Japan, Japan: AST), a fully automated treponemal antibody test, as a...
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Correlation of Chromosomal Aberrations with Prognostic Markers in Multiple Myeloma Patients- A Single Institution Study

Lee JW, Lee JK, Hong YJ, Hong SI, Chang YH

BACKGROUND: Immunoglobulin heavy chain (IGH) gene rearrangement, 13q14 deletion and trisomy 1q are frequently observed in Korean patients with multiple myeloma. The purpose of our study was to analyze the...
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Production and Characterization of Anti-Staphylococcal Toxic Shock Syndrome Toxin-1 Monoclonal Antibody

Park JS, Kim JS, Yi J, Kim EC

BACKGROUND: Recently the association between the virulence factors of Staphylococcus aureus and the outcome of the patients infected with the organism appears to be the subject of active investigation. Toxic...
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Genetic Counseling Can Influence the Course of a Suspected Familial Cancer Syndrome Patient: From a Case of Li-Fraumeni Like Syndrome with a Germline Mutation in the TP53 Gene

Hwang SM, Lee ES, Shin SH, Kong SY

We report a 26-yr-old female patient with bilateral breast cancer who was clinically diagnosed with Li-Fraumeni like syndrome (LFL) and subsequently found to have a germline mutation of the TP53...
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Allele and Haplotype Frequencies of Human Leukocyte Antigen-A, -B, and -DR Loci in Koreans: DNA Typing of 1,500 Cord Blood Units

Whang DH, Yang YS, Hong HK

BACKGROUND: The HLA system is known to be the most polymorphic genetic system in human, and HLA allele and haplotype distribution varies widely among different ethnic groups. This study was...
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Extended-spectrum beta-Lactamases: Implications for the Clinical Laboratory and Therapy

Harada S, Ishii Y, Yamaguchi

Production of extended-spectrum beta-lactamase (ESBL) is one of the most important resistance mechanisms that hamper the antimicrobial treatment of infections caused by Enterobacteriaceae. ESBLs are classified into several groups according...
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Four Cases of Hematologic Malignancy Following Radioactive Iodine Therapy for Thyroid Cancer

Im M, Lee JK, Hong YJ, Hong SI, Kang HJ, Na II, Ryoo BY, Cheon GJ, Lee HN, Chang YH

Ionizing radiation including I131 might produce chromosomal translocation, causing hematologic malignancy. The incidence of leukemia following radioactive iodine treatment for thyroid cancer has been reported to be approximately 0.1 to...
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Two Cases of Vancomycin-intermediate Staphylococcus aureus Isolated from Joint Tissue or Wound

Hong KH, Park JS, Kim EC

Since its first isolation in 1997, vancomycin-intermediate Staphylococcus aureus (VISA) has been a clinical concern because it may lead to treatment failure. Up to the present, there were two reports...
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Erratum: Panton-Valentine Leukocidin Positive Staphylococcus aureus Isolated from Blood in Korea

Kim JS, Park JS, Song W, Kim HS, Cho HC, Lee KM, Kim EC

This erratum is being published to correct the printing error on page 286 of the article entitled 'Panton-Valentine leukocidin positive Staphylococcus aureus isolated from blood in Korea' by Kim JS,...
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Utility of D-dimer Assay for Diagnosing Pulmonary Embolism: Single Institute Study

Park R, Seo YI, Yoon SG, Choi TY, Shin JW, Uh ST, Kim YK

BACKGROUND: Pulmonary embolism (PE) presents with diverse non-specific signs and symptoms and its diagnosis mainly depends on diagnostic imaging tests which are laborious and not cost-effective, and only a small...
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Molecular and Clinical Characteristics of Myotonic Dystrophy Type 1 in Koreans

Kim SY, Kim JY, Kim GP, Sung JJ, Lim KS, Lee KW, Chae JH, Hong YH, Seong MW, Park SS

BACKGROUND: Myotonic dystrophy type 1 (DM1) is an autosomal-dominant muscular dystrophy caused by expansion of cytosine-thymine-guanine (CTG) trinucleotide repeats in the myotonic dystrophy protein kinase (DMPK) gene. The clinical features...
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Human Telomerase Reverse Transcriptase (hTERT): A Target Molecule for the Treatment of Cisplatin-resistant Tumors

Park YP, Kim KD, Kang SH, Yoon DY, Park JW, Kim JW, Lee HG

BACKGROUND: Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme that is required for telomerase activity (TA) and cancer progression. Telomerase inhibition or inactivation increases cellular sensitivity to UV irradiation,...
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Diagnostic Utility of AxSYM Anti-Cyclic Citrullinated Peptide Antibody Assay

Kim KE, Kim KH, Woo KS, Han JY, Kim JM, Lee SW, Chung WT

BACKGROUND: The presence of rheumatoid factor (RF) is one of the classification criteria of the American College of Rheumatology (ACR) for rheumatoid arthritis (RA), but it has a limitation of...
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Measurement of Amylase in Saliva Collected by Salivette

Park JR, Kim MH, Woo J, Lee SJ, Song KE

BACKGROUND: Saliva is increasingly being used as a specimen for systemic disease as well as for oral health status. Especially, salivary amylase has been studied as an excellent index for...
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