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Current practice for diagnosing immediate drug hypersensitivity reactions in Korea

Kang SY, Yang MS, Song WJ, Cho SH

Background/Aims: Skin (STs) and drug provocation (DPTs) tests are essential for identifying the culprit drugs causing drug hypersensitivity reactions (DHRs). Several protocols have been developed for the identification of some...
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Effectiveness and safety of elbasvir/grazoprevir in Korean patients with hepatitis C virus infection: a nationwide real-world study

Jang ES, Kim KA, Kim YS, Kim IH, Lee BS, Lee YJ, Chung WJ, Jeong SH

Background/Aim: This study aimed to establish the real-world effectiveness and safety of grazoprevir/elbasvir (EBR/GZR) therapy in South Korea. Methods: A total of 242 patients with chronic hepatitis C virus (HCV) genotype...
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Feasibility of primary percutaneous coronary intervention via the distal radial approach in patients with ST-elevation myocardial infarction

Kim Y, Lee JW, Lee SY, Bae JW, Lee SJ, Jeong MH, Lee SH, Ahn Y

Background/Aims: Recently, distal radial approach (DRA), called as snuffbox approach, has gained the interest of interventional cardiologists, but there is a lack of data about the feasibility of DRA as...
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Effect of stent placement on stone recurrence and post-procedural cholangitis after endoscopic removal of common bile duct stones

Choi JH, Lee TY, Cheon YK

Background/Aims: After endoscopic treatment of common bile duct (CBD) stones, recurrence of choledocholithiasis due to small stone fragments and post-endoscopic retrograde cholangiopancreatography (post-ERCP) cholangitis can occur. We determined the effect...
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Long-term efficacy of vasodilating β-blocker in patients with acute myocardial infarction: nationwide multicenter prospective registry

Chung J, Han JK, Yang HM, Park KW, Kang HJ, Koo BK, Jeong MH, Kim HS, on behalf of investigators for Korea Acute Myocardial Infarction Registry (KAMIR)

Background/Aims: Long-term benefit of vasodilating β-blockers is unknown. This study aimed to investigate the long-term benefit of vasodilating β-blockers over conventional β-blockers in patients with acute myocardial infarction (AMI). Methods: Using...
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Colonoscopy quality in community hospitals and nonhospital facilities in Korea

Lee JG, Han DS, Joo YE, Myung DS, Park DI, Kim SK, Jung Y, Lee WH, Kim ES, Yoon JS, Eun CS

Background/Aims: High-quality colonoscopy is essential to reduce colorectal cancer-related deaths. Little is known about colonoscopy quality in non-academic practice settings. We aimed to evaluate the quality of colonoscopies performed in...
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Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea

Seo J, Son M

Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity...
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Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970

Koo BS, Jeong HJ, Son CN, Kim SH, Kim HJ, Kim GH, Jun JB

Background/Aims: We investigated the distribution of serum uric acid (SUA) levels and estimated the prevalence of hyperuricemia and hypouricemia in the Korean population. Methods: This cross-sectional study used data from the...
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Surtuin 1 as a potential prognostic biomarker in very elderly patients with colorectal cancer

Lee GJ, Jung YH, Kim TJ, Chong Y, Jeong SW, Lee IK, Woo IS

Background/Aims: Colorectal cancer (CRC) rate increases with aging. Aging-related proteins, such as sirtuins (SIRTs) may be a potential therapeutic target in the elderly patients with CRC. The clinical implications of...
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Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019

Kim JW, Kim EJ, Kwon HH, Jung CY, Kim KC, Choe JY, Hong HL

Background/Aims: The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment...
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Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy

Kim S, Han D, Choi JH, Park EJ, Shin DG, Kang MK, Choi S, Lee N, Cho JR

Background/Aims: Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has been shown to reduce ischemic events at the expense of increased bleeding. However, limited data are...
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Effect of body mass index and abdominal obesity on mortality after percutaneous coronary intervention: a nationwide, population-based study

Song WH, Bae EH, Ahn JC, Oh TR, Kim YH, Kim JS, Kim SW, Kim SW, Han KD, Lim SY

Background/Aims: We investigated the impact of obesity on the clinical outcomes following percutaneous coronary intervention (PCI). Methods: We included South Koreans aged > 20 years who underwent the Korean National Health...
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Comparison of loss of response between anti-tumor necrosis factor alone and combined use with immunomodulators in patients with inflammatory bowel disease

Hong SW, Park J, Yoon H, Yang HR, Shin CM, Park YS, Kim N, Lee DH, Kim JS

Background/Aims: Combination therapy with immunomodulators (IMMs) was proposed as a strategy to prevent the development of loss of response (LOR) to anti-tumor necrosis factor (TNF) for patients with inflammatory bowel...
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Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey

Ha J, Lee J, Lim DJ, Lee JM, Chang SA, Kang MI, Kim MH

Background/Aims: Thyroid hormones are involved in wide range of glucose metabolism functions. Overt thyroid dysfunctions are related to altered glucose homeostasis. However, it is not conclusive as to whether subtle...
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Effects of renin-angiotensin system blockers on the risk and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with hypertension

Lee J, Jo SJ, Cho Y, Lee JH, Oh IY, Park JJ, Cho YS, Choi DJ

Background/Aims: There are concerns that the use of renin-angiotensin system (RAS) blockers may increase the risk of being infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or progressing to...
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Physical activity of Korean cancer survivors is associated with age and sex

Park JH, Lee JS, Ko YH, Kim YH

Background/Aims: This study aimed to assess adherence to physical activity guidelines in cancer survivors and to investigate related factors. Methods: The cross-sectional data of 39,845 community-dwelling participants aged ≥ 20 years...
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Different roles of surveillance positron emission tomography according to the histologic subtype of non-Hodgkin’s lymphoma

Kim YR, Kim SJ, Cheong JW, Kim Y, Jang JE, Cho H, Chung H, Min YH, Yang WI, Cho A, Kim JS

Background/Aims: Although the use of surveillance 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is discouraged in patients with diffuse large B-cell lymphoma, its usefulness in different subtypes has not been...
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Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells

Na YJ, Yu ES, Kim DS, Lee DH, Oh SC, Choi CW

Background/Aims: Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years. In addition, a considerable number of...
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Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis

Kim KW, Kim BM, Won JY, Min HK, Lee SJ, Lee SH, Kim HR

Background/Aims: The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA). Methods: We evaluated the effect of tocotrienol on IL-17-induced receptor activator of nuclear...
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A genome wide association study for lung function in the Korean population using an exome array

Lee KS, Kim KH, Oh YM, Han B, Kim WJ

Background/Aims: Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked...
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