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Clinical Significance of Co-expression of Aberrant Antigens in Acute Leukemia

Jeong SH, Lee HW, Kang SY, Ahn MS, Hwang YH, Choi JH, Kim HC, Cho SR, Park JS

BACKGROUND: Acute leukemias co-expressing myeloid and lymphoid antigens but does not meet the criteria for biphenotypic acute leukemia (BAL) is common, however its clinical significance is not fully defined. METHODS: In...
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Difference in Viability of CD34+Cells in Cryopreserved Cord Blood According to Evaluation Methods

Ahn MS, Eom YW, Park JS, Choi JH, Kang SY, Lee HW, Yang MS, Kim HE, Jang IK, Lee JE, Kim YJ, Kim HC, Jeong SH

BACKGROUND: On performing umbilical cord blood (UCB) transplantation, faster engraftment may lead better clinical outcome. Because transplanted viable cell count in UCB is related to the engraftment, accurate evaluation of...
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A Case of Acute Biphenotype Leukemia after Diagnosis of Pulmonary Alveolar Proteinosis

Cheong HR, Lee HR, Park SB, Kim HJ, Lee NR, Cheong JH, Kim MR, Choi YJ, Chung JS, Cho GJ

We present the case of a 34-year-old man with acute biphenotype leukemia that co-expressed B-lymphoid and myeloid antigen after the diagnosis of pulmonary alveolar proteinosis (PAP). The diagnosis of PAP...
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Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia

Song SH, Roh YW, Ahn YW, Kim YJ, Byoun YS, Choi JY, Hwang DW, Park BB, Choi JH, Kim IS, Kim BK, Lee YY

The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid...
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A Case of Immune Thrombocytopenic Purpura Developing after Treatment for Non-Hodgkin's Lymphoma

Lee HY, Jeong DJ, Lee DG, Chun K, Ryu SW, Song SY

Immune thrombocytopenic purpura (ITP) can be classified as primary or secondary according to the presence of an underlying non-malignant or malignant disorder, including lymphoproliferative disorders. The estimated prevalence of ITP...
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Primary Diffuse Large B Cell Lymphoma of the Bladder

Kim SK, Kim MH, Lee N, Cha D, Kim H, Choi YJ, Chung JS, Cho GJ

Primary malignant lymphoma of the urinary bladder is a rare disease, and it accounts for only 0.2% of all the cases of extranodal lymphoma. The prognosis of primary bladder lymphoma...
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Plasmablastic Lymphoma in a Human Immunodeficiency Virus-negative Patient: A Case Report and Review of the Literature

Lim JH, Joo WC, Choi SJ, Kim JS, Yi HG, Lee MH, Lee JS, Kim CS

The plasmablastic lymphomas (PBLs) are an aggressive group of non-Hodgkin's lymphomas occurring primarily in human immunodeficiency virus (HIV)-infected individuals with absolute CD4 counts less than 200 per microliter. It was...
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Toxic Epidermal Necrolysis after Rituximab Therapy for Immune Thrombocytopenic Purpura

Bae SY, Kim YK, Yoon JY, Lee SJ, Kim DE, Rew SY, Hong SD, Jo DH, Hwang JI, Bae WK, Shim HJ, Ahn JS, Yang DH, Cho SH, Lee JJ, Chung IJ, Kim HJ

Rituximab is a chimeric monoclonal antibody that specifically targets the CD20 molecule on the B cell surface. Although rituximab was originally introduced for the treatment of lymphoid neoplasms such as...
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Prognostic Significance of FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype

Lee JY, Joo YD, Oh SH, Shin JH, Kim HR, Lee SM, Lee JN

BACKGROUND: Activating mutations of the fms-like tyrosine kinase 3 gene (FLT3) by internal tandem duplication (ITD) in the juxtamembrane region are found in 20~30% of the adults with acute myeloid...
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The Effect of an Ectopic Overexpression of MnSOD in Mouse Hematopoietic Stem Cells

Park MR, Xu F, Cheng T

BACKGROUND: Intracellular reactive oxygen species (ROS) have dual effects depending on their cellular level. ROS act as secondary messengers at a low concentration, although ROS exhaust the hematopoietic stem cell...
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