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Enforced Expression of BMI-1 in Postnatal Human CD34+ Cells Promotes Erythroid Differentiation

Lee G, Kim BS, Shieh JH, Moore MA

BACKGROUND: The Polycomb-group gene Bmi-1 is known to be a molecular regulator of self-renewal of normal and leukemic stem cells and be involved in various aspects of cellular proliferation, differentiation,...
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Cord Blood-Current Status and Perspective

Lee YH

Umbilical cord blood (CB) is increasingly used as a source of stem cells to repopulate bone marrow in the treatment of life-threatening diseases in children and adults. I review the...
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Novel PML-RARA Fusion Gene on Chromosome 17 in Acute Promyelocytic Leukemia with Normal Chromosome 15 and 17

Kim KH, Won JH, Jeung KJ, Lee SC, Kim HJ, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Park HS, Lee YK

We describe a patient with acute promyelocytic leukemia (APL) with no detectable cytogenetic abnormality of either chromosomes 15 or 17 who nevertheless had juxtaposition of promyelocytic leukemia (PML) and retinoic...
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FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype

Kim SH, Kim YK, Lee IK, Jo DY, Won JH, Kwak JY, Yim CY, Park MR, Yang DH, Cho SH, Lee JJ, Chung IJ, Kim HJ

BACKGROUND: The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance....
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Generation and Qualification of Functionally Active Leukemia-derived DCs from Malignant Blasts in Acute Leukemia

Baek S, Jung CW, Kim MJ, Kim K, Ahn JS, Lee H

BACKGROUND: Dendritic cells (DCs) are increasingly being utilized for anti-cancer immunotherapy. Acute myeloid leukemia (AML) blasts are able to generate leukemia-derived DC. Advances in culture techniques and AML-DC characterization justify...
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Aging Effects on Dendritic Cells after Total Body Irradiation in Mice

Kim DH, Kim MJ, Cho JH, Lim NK, Park JI, Jeong SH, Lee HW, Kang SY, Choi JH, Kim HC, Park JS

BACKGROUND: It is still obscure how dendritic cells (DCs) can orchestrate whole immune reactions according to the host age. We studied changes of murine splenic DCs after total body irradiation...
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A Case of High Dose Cytosine Arabinoside Induced Stevens-Johnson Syndrome in a Patient with Malignant Lymphoma

An JW, Lee MA, Ko YH, Nam SM, Chung MK, Moon SJ, Kang JH, Hong YS, Lee KS

Many chemotherapeutic agents induce variable cutaneous adverse reactions. Among the side effects, Stevens-Johnson syndrome is rare, but a fatal complication. There are two prior reports of cytosine arabinoside (ARA-C) induced...
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A Pediatric Case of Autoimmune Hemolytic Anemia followed by Excessive Thrombocytosis and Leukocytosis

Jea SJ, Kim SY, Choi BM, Lee JH, Lee KC, Woo CW

Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directed against red blood cells (RBCs). It is usually accompanied by normal white blood cell (WBC) and platelet counts....
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A Case of Immunoglobulin Therapy for Pure Red Cell Aplasia Induced by Parvovirus B19

Cho JH, Choi WS, Huh KR, Won JE, Lee YK, Zang DY, Kim HJ

Human parvovirus B19 infection could be manifested as pure red cell aplasia or chronic anemia in immunocompromised host. The patient was 35-year-old female who had been diagnosed as non-Hodgkin lymphoma,...
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Therapeutic Efficacy of a Single Dose of Anti-D Immunoglobulin 50 microgram/kg in Childhood Acute Immune Thrombocytopenic Purpura

Nam KL, Cho SH, Yang SW, Son DW, Jeon IS

BACKGROUND: To investigate the efficacy and adverse effects of a single dose of anti-D immunoglobulin (50 microgram/kg) in Korean children with acute immune thrombocytopenic purpura (ITP). METHODS: We serially evaluated the...
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Monoclonal Proteinuria as a Prognostic Factor for Multiple Myeloma Patients with Intact Immunoglobulin Type

Koo DH, Oh JS, Choi SH, Park HG, Lee SS, Kim MK, Sym SJ, Min WK, Kim S, Suh S

BACKGROUND: Urine/serum protein electrophoresis (PEP) and immunofixation electrophoresis (IEP) for monoclonal protein (M-protein) are used for initial evaluation in patients with multiple myeloma. We evaluated the prognostic significance of M-proteinuria...
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The Association between Cytogenetic Abnormalities and Clinical Outcomes Based on Prognostic Factors of the Children Cancer Group (CCG) in Pediatric Patients with Acute Leukemia: Two Institutional Retrospective Studies

Bae JJ, Jang YS, Kim JY, Lim YJ, Park HK, Han JY, Lee YH

BACKGROUND: We investigated the incidence of cytogenetic abnormalities as well as the correlation of the cytogenetic abnormalities and clinical outcomes based on the prognostic factors of the Children Cancer Group...
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Donor Lymphocyte Infusions for Patients with Relapsed Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: a 10-year Experience of Seoul National University Hospital

Kim JW, Kim BS, Kim DY, Kim KH, Rhee JY, Bang SM, Kim I, Yoon SS, Lee JS, Park S, Kim BK

BACKGROUND: Donor lymphocyte infusion (DLI) has been established as a salvage therapy for patients with relapsed leukemia after allogeneic hematopoietic stem cell transplantation (HSCT). However, its benefit can be limited...
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Evaluation of a Blood Coagulation Factor XIII Assay Kit

Ryu S, An SS, Suh IB

BACKGROUND: Plasma coagulation factor XIII (FXIII) catalyzes the formation of covalent bounds between fibrin monomers, thus stabilizing the fibrin clot and increasing its resistance to fibrinolysis. Alteration of FXIII may...
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Hereditary Hemolytic Anemia in Korea: a Retrospective Study from 1997 to 2006

Cho HS, Hah JO, Kang IJ, Kang HJ, Kwak JY, Koo HH, Kook H, Kim BK, Kim SK, Kim ST, Kim YD, Kim JY, Kim CS, Ghim T, Kim HS, Park SG, Park SY, Park JE, Bang SM, Seo JJ, Suh CI, Sohn SK, Shin HJ, Shin HY, Ahn HS, Oh D, Yoo ES, Lyu CJ, Yoon SS, Lee KS, Lee KC, Lee KH, Lee SY, Lee YH, Lee JA, Lee JS, Lim YT, Lim JY, Im HJ, Jeong DC, Chong SY, Chung JS, Jung HL, Cho GJ, Jo DY, Jin JY, Choi EJ, Hyun MS, Hwang PH

BACKGROUND: The aim of this study was to investigate the prevalence, clinical and laboratory findings of hereditary hemolytic anemia (HHA) in Korea from 1997 to 2006 and to develop the...
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