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Azacitidine-induced Hepatotoxicity in a Patient with Myelodysplastic Syndrome

Kim JS, Lim JH, Yi HG, Park H, Lee MH, Kim CS

Hematopoietic stem cell transplantation remains the only curative option for myelodysplastic syndrome (MDS), but the prevalence of the disease in elderly people limits broad application of the procedure, particularly in...
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Quantifing the Circulating Epstein-Barr Virus (EBV) DNA to Monitor a Case of Aggressive Natural Killer Cell Leukemia

Yi SY, Kim HS, Jun HJ, Yang JH, Ko YH, Ki CS, Kim WS

Epstein-Barr virus (EBV) infection is associated with various lymphoproliferative diseases, including Hodgkin lymphoma, extranodal NK/T cell lymphoma, aggressive NK cell leukemia, Burkitt lymphoma and post-transplant lymphoproliferative disorder. In the recent...
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A Case of Bicytopenia Combined with Littoral Cell Angioma

Song MK, Seol YM, Park YE, An SK, Choi YJ, Shin HJ, Chung JS, Cho GJ

Littoral cell angioma is a recently described vascular tumor of spleen with an unknown etiology. We present a case in a 74-year-old woman with severe anemia, thrombocytopenia and palpable splenomegaly....
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The Clinical Guidelines for Myelodysplastic Syndrome

Cheong JW, Kook H, Bang SM, Lee JH, Joo YD, Kim I, Kim HJ, Park CJ, Park HJ, Ahn JS, Yoon SS, Won JH, Lee MH, Jung CW, Jo DY, Cho B, Han KJ, Min YH, Kim SH

The myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis associated with multilineage cytopenias leading to serious morbidity or mortality, and the additional risk of leukemic transformation. The management of patients...
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Hematopoietic Stem Cell Transplantation with Using Multinational Unrelated Donors for Acute Myelogenous Leukemia

Kim HJ, Min WS, Eom KS, Cho BS, Kim SY, Bok JN, Kim KS, Min CK, Lee S, Cho SG, Kim DW, Lee JW, Kim CC

BACKGROUND: Many AML patients have received hematopoietic stem cell transplantation (HSCT) from HLA-matched unrelated donors. According to many of the previous reports, those patients could achieve long-term, disease-free survival after...
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A Case of Pure Red Cell Aplasia Associated with Hashimoto Disease

Kim HG, Lee GW, Kim KM, Kang MH, Ju JH, Kang JH, Lee JS

Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood and isolated severe erythroblastopenia with no abnormalities of the granulopoiesis and megakaryopoiesis in...
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A Case of Unspecified Mature T-cell Leukemia with Clover-shaped, Multi-lobated Nuclei

Lee ST, Park SY, Kim HJ, Kim SH

Mature T-cell leukemias are a group of neoplasms derived from mature or post-thymic T-cells, and a number of distinctive disease entities have been defined in the World Health Organization (WHO)...
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A Case of Chronic Neutrophilic Leukemia with Multiple Myeloma and an Increased Function of Her Neutrophils

Kim S, Park CJ, Lee KH, Jang S, Chi HS, Seo EJ

We describe here a 64-year-old woman who simultaneously presented with chronic neutrophilic leukemia (CNL) and multiple myeloma (MM). The patient presented with mature neutrophilic leukocytosis, hepatosplenomegaly, the absence of Philadelphia...
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The Expression of p16 in Diffuse Large B-cell Lymphoma and Its Prognostic Implications

Kim DH, Sohn JH, Kim MK, Lee KB, Kang SH, Chae SW

BACKGROUND: The molecular mechanisms that are responsible for the initiation and progression of diffuse large B-cell lymphoma are largely unknown. p16 is an inhibitor of cyclin-dependent kinase and its inactivation...
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Pharmacokinetics of High-dose Intravenous Melphalan in Patients Undergoing Autologous Stem Cell Transplantation

Lee SY, Kim JA, Lee JW, Koo HJ, Kim HK

BACKGROUND: Melphalan is frequently used in conditioning regimens prior to autologous stem cell transplantation. The pharmacokinetics of melphalan have shown great interindividual variations. This study aims to investigate the pharmacokinetics...
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A Case of Henoch-Schonlein Purpura Associated with Diffuse Large B Cell Lymphoma

Kim ID, Lee SG, Lee HJ, Jo WS, Choi YJ, Shin HJ, Chung JS, Cho GJ, Lee EY

A 69-year-old female was referred to our institution due to abdominal pain and palpable purpura on both buttocks and legs. A skin biopsy of her purpura revealed granulocyte infiltration and...
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Anti-tumor Cytotoxicity of Allogeneic Neuroblastoma Tumor Antigen-loaded Dendiritic Cells

Park HJ, Shin HY, Ahn HS

BACKGROUND: Despite of aggressive treatments, the long-term survival rate is about 30% in stage 4 neuroblastoma (NBL). Recently, dendritic cell (DC)-based immunotherapy is emerging as a promising tool in cancer...
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Practical Evaluation of Engraftment and Mixed Chimerism Using PCR Amplification of a Microsatellite in the Class II Eb Gene in Murine MHC-mismatched, Nonmyeloablative Bone Marrow Transplantation

Roh SY, Park MJ, Park H, Cho SG, Min SY, Lee JW, Min WS, Kim CC, Kim HY, Chang HS

BACKGROUND: Although engraftment following murine allogeneic bone marrow transplantation (BMT) is most commonly confirmed by H2 typing using flow cytometry, recipient mice can be seriously injured during peripheral blood (PB)...
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The Role of Bone Marrow Mononuclear Cells in Angiogenesis in Mouse Hind Limb Ischemic Model

Cho HM, Hong JW, Kim JG, Kim JA

BACKGROUND: Angiogenesis is enhanced in the ischemic tissues after the injection of bone marrow cells (BMCs). However the exact mechanisms for this are not yet fully understood. METHODS: A unilateral ischemic...
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Viruria in Adult Hemorrhagic Cystitis Patients Following Allogeneic Hematopoietic Stem Cell Transplantation and Implication of Antiviral Treatment

Kim SY, Lee JW, Lee KM, Cho BS, Eom KS, Kim YJ, Lee S, Min CK, Kim HJ, Cho SG, Kim DW, Min WS, Kim CC

BACKGROUND: Viruria is frequently detected in patients who have had hemorrhagic cystitis (HC) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Urinary viruses, especially BK virus, have been suggested as a...
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