- Protein kinase C modulates telomerase activity in human cervical cancer cells
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Kim YW, Hur SY, Kim TE, Lee JM, Namkoong S, Ki IK, Kim JW
- KMID: 938880
- Exp Mol Med.
- 2001 Sep;33(3):156-163.
Telomerase, a ribonucleoprotein reverse transcriptase that extends telomeres of eukaryotic chromosomes is repressed in normal somatic cells but is activated during development and neoplasia. The regulation mechanism of telomerase activity... -
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- Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme
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Song MS, Jeong JS, Cho KS, Lee SW
- KMID: 1091067
- Exp Mol Med.
- 2007 Dec;39(6):722-732.
A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in... -
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