- Mutations of p53 associated with pancreatic cancer and therapeutic implications
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Voutsadakis IA
- KMID: 2519287
- Ann Hepatobiliary Pancreat Surg.
- 2021 Aug;25(3):315-327.
- doi: 10.14701/ahbps.2021.25.3.315
Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis. Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease is invariably fatal with survival time less than... -
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- Novel Therapeutics for Recurrent or Metastatic Gastric Cancer
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Lee HY, Ko YH
- KMID: 2435030
- Korean J Med.
- 2018 Feb;93(1):14-24.
- doi: 10.3904/kjm.2018.93.1.14
Despite advances in cancer therapy, gastric cancer has a poor prognosis and high cancer-related mortality. Based on the molecular characteristics of cancer, specific targeted therapies have shown clinical benefits for... -
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- Targeting the Phosphatidylinositol-3-kinase Pathway in Gastric Cancer: Can Omics Improve Outcomes?
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Tran P, Nguyen C, Klempner S
- KMID: 2362506
- Int Neurourol J.
- 2016 Nov;20(Suppl 2):S131-S140.
- doi: 10.5213/inj.1632740.370
Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies. Therapeutic targeting of PI3K pathway components has improved outcomes in chronic lymphocytic leukemia, kidney cancer,... -
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- Molecular Pathogenesis and Targeted Therapies in Well-Differentiated Thyroid Carcinoma
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Kim JG
- KMID: 2169455
- Endocrinol Metab.
- 2014 Sep;29(3):211-216.
- doi: 10.3803/EnM.2014.29.3.211
Four proto-oncogenes commonly associated with well-differentiated thyroid carcinoma, rearranged during transfection (RET)/papillary thyroid cancer, BRAF, RAS, and PAX8/peroxisome proliferator activated receptor-gamma, may carry diagnostic and prognostic significance. These oncogenes can... -
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- Divide and Conquer: Progress in the Molecular Stratification of Cancer
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Tan P
- KMID: 1758604
- Yonsei Med J.
- 2009 Aug;50(4):464-473.
- doi: 10.3349/ymj.2009.50.4.464
Cancer remains an outstanding cause of global morbidity and mortality, despite intensive research and unprecedented insights into the basic mechanisms of cancer development. A plethora of clinical and experimental evidence... -
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