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Necessity of pharyngeal anesthesia during transoral gastrointestinal endoscopy: a randomized clinical trial

Hayashi T, Asahina Y, Takeda Y, Miyazawa M, Takatori H, Kido H, Seishima J, Iida N, Kitamura K, Terashima T, Miyagi S, Toyama T, Mizukoshi E, Yamashita T

Background/Aims: The necessity for pharyngeal anesthesia during upper gastrointestinal endoscopy is controversial. This study aimed to compare the observation ability with and without pharyngeal anesthesia under midazolam sedation. Methods: This prospective,...
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Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes

Tsukamoto , Takeuchi M, Kawaguchi , Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C

LR11, also known as SorLA or SORL1, is a type-I membrane protein from which a large extracellular part, soluble LR11 (sLR11), is released by proteolytic shedding on cleavage with a...
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