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Molecular Cloning of Mouse FK-506 Binding Protein 12.6 Gene and Its Biological Function and Expression Patterns in the Various Models of Heart Disease

Cho MC, Piao H, Youn TJ, Kim DW

BACKGROUND AND OBJECTIVES: The FK-506 binding protein 12 (FKBP12) regulates intracellular Ca2+ release by stabilizing the Ca2+-induced Ca2+-release channel (ryanodine receptor) in skeletal muscle. It has been recently shown that...
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FKBP-12 Exhibits an Inhibitory Activity on Calcium Oxalate Crystal Growth in Vitro

Han IS, Nakagawa Y, Park JW, Suh MH, Suh SI, Shin SW, Ahn SY, Choe BK

Urolithiasis and calcium oxalate crystal deposition diseases are still significant medical problems. In the course of nephrocalcin cDNA cloning, we have identified FKBP-12 as an inhibitory molecule of calcium oxalate...
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Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells

Lee Y, Broxmeyer , Mantel C, Kwon HJ, Kim JW, Kim JS, Kwon D, Choe IS

  • KMID: 1094704
  • Exp Mol Med.
  • 2003 Jun;35(3):222-226.
Stem cell factor (SCF) is an early-acting cytokine inducing proliferative synergy with other cytokines in hematopoietic cells. We earlier showed that p21 was synergistically induced in SCF synergy and the...
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