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Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice

Hong M, Kim M, Kim TW, Park SS, Kim MK, Park YH, Sung YH, Shin MS

Purpose: Thrombotic stroke is a type of ischemic stroke characterized by motor dysfunction and memory impairments. In the present study, the effect of treadmill exercise on motor function and short-term...
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Connecting the dots between SHP2 and glutamate receptors

Ryu HH, Kim SY, Lee YS

SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological...
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Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits

Sun Wc, Wang J, Cai D, Pei L

  • KMID: 2508472
  • Exp Neurobiol.
  • 2020 Oct;29(5):356-375.
  • doi: 10.5607/en20032
Dexmedetomidine (DEX) has neuroprotective effects and its efficacy was determined in propofol-treated pups. Postnatal day (P) 7 rats were exposed to propofol and DEX to investigate the induced apoptosis-related gene...
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Sequential Activation of AMPA Receptors and Glial Cells in a Pain Model of Lumbar Spine Disc Herniation

Kwak DG, Lee DG

Objective To investigate the glial cell and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activity after surgery for disc herniation pain model. Methods In total, 83 Sprague-Dawley rats were randomly assigned to the following...
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β-Amyrin Ameliorates Alzheimer’s Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus

Park HJ, Kwon H, Lee JH, Cho E, Lee YC, Moon M, Jun M, Kim DH, Jung JW

Alzheimer’s disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface...
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Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2

Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H

Silent information regulator 2 (Sirtuin2 / SIRT2) is a NAD⁺-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins...
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Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease

Tang J, Oliveros A, Jang MH

Synapses are sites of high energy demand which are dependent on high levels of mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are key for maintenance of functional neurotransmission and...
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New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders

Hussaini S, Jang MH

Previously believed to solely play a supportive role in the central nervous system, astrocytes are now considered active players in normal brain function. Evidence in recent decades extends their contributions...
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Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

Kim YJ

Transcranial direct current stimulation (tDCS) is one of the brain stimulation techniques, which considered as an alternative treatment for Alzheimer's disease (AD). In AD, cognitive, behavior, and functional deteriorations are...
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Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission

Park HJ, Lee S, Jung JW, Lee YC, Choi SM, Kim DH

Consumption of high doses of ethanol can lead to amnesia, which often manifests as a blackout. These blackouts experienced by ethanol consumers may be a major cause of the social...
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Metabotropic glutamate receptor dependent long-term depression in the cortex

Kang SJ, Kaang BK

Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The...
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Neural circuit remodeling and structural plasticity in the cortex during chronic pain

Kim W, Kim SK

Damage in the periphery or spinal cord induces maladaptive plastic changes along the somatosensory nervous system from the periphery to the cortex, often leading to chronic pain. Although the role...
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Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency

Kim HB, Kwon BJ, Cho HJ, Kim JW, Chon JW, Do MH, Park SY, Kim SY, Maeng SH, Park YK, Park JH

Artemisia princeps (AP) is a flowering perennial used as a traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus...
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Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity

Kim S, Kim T, Lee HR, Kong YY, Kaang BK

Notch signaling is a key regulator of neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-2 (Mib2) is an essential positive...
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Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization

Park JM, Jung SC, Eun SY

At central synapses, activity-dependent synaptic plasticity has a crucial role in information processing, storage, learning, and memory under both physiological and pathological conditions. One widely accepted model of learning mechanism...
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The Role of AMPA Receptors in Synaptic Plasticity by Drugs of Abuse

Kwak MJ, Kim JH

Dopamine has long time considered as the main player in drug addiction. However, growing body of literature strongly supports a role for glutamate in addiction. 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors,...
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Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon

Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS

Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by...
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Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders

Chung L, Bey AL, Jiang YH

Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and...
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Effects of Saccharin Intake on Hippocampal and Cortical Plasticity in Juvenile and Adolescent Rats

Park JS, Yoo SB, Kim JY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K, Jahng JW, Choi SY

The sensory system is developed and optimized by experiences given in the early phase of life in association with other regions of the nervous system. To date, many studies have...
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Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang HJ, Cho KH, Park SW, Kim MJ, Yoon SH, Rhie DJ

Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a...
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