- ROS Scavenger, Ebselen, Has No Preventive Effect in New Hearing Loss Model Using a Cholesterol-Chelating Agent
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Lee MY, Kabara LL, Swiderski , Raphael Y, Duncan RK, Kim YH
- KMID: 2447576
- J Audiol Otol.
- 2019 Apr;23(2):69-75.
- doi: 10.7874/jao.2018.00255
BACKGROUND AND OBJECTIVES: The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage... -
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- Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation
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Swiderski , Bindon R, Trieu J, Naim T, Schokman S, Swaminathan M, Leembruggen AJL, Hill-Yardin EL, Koopman R, Bornstein , Lynch GS
- KMID: 2500658
- J Neurogastroenterol Motil.
- 2020 Jan;26(1):133-146.
- doi: 10.5056/jnm19029
Background/Aims Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) function likely resulting from dysregulated nitric oxide production. Compounds increasing neuronal nitric oxide synthase expression and/or activity... -
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