- Altered Transendothelial Transport of Hormones as a Contributor to Diabetes
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Yoon N, Dang TQ, Chasiotis , Kelly SP, Sweeney G
- KMID: 2280699
- Diabetes Metab J.
- 2014 Apr;38(2):92-99.
- doi: 10.4093/dmj.2014.38.2.92
The vascular endothelium is a dynamic structure responsible for the separation and regulated movement of biological material between circulation and interstitial fluid. Hormones and nutrients can move across the endothelium... -
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- Regulation of Iron and Its Significance in Obesity and Complications
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Chan YK, Sung HK, Sweeney G
- KMID: 2271135
- Korean J Obes.
- 2014 Dec;23(4):222-230.
- doi: 10.7570/kjo.2014.23.4.222
Iron is an essential micronutrient with important roles in many critical physiological processes, especially as a structural component of hemoglobin responsible for oxygen transport. Iron homeostasis is tightly regulated, yet... -
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- Functional and Mechanistic Integration of Infection and the Metabolic Syndrome
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Sommer P, Sweeney G
- KMID: 2222379
- Korean Diabetes J.
- 2010 Apr;34(2):71-76.
- doi: 10.4093/kdj.2010.34.2.71
The metabolic syndrome refers to a well defined group of risk factors, including central obesity and inflammation, for the development of diabetes and cardiovascular disease. Interestingly, many studies have recently... -
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- The association between PGC-1a and Alzheimer's disease
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Sweeney G, Song J
- KMID: 2308926
- Anat Cell Biol.
- 2016 Mar;49(1):1-6.
- doi: 10.5115/acb.2016.49.1.1
Alzheimer's disease (AD) is a neurodegenerative disorder and its reported pathophysiological features in the brain include the deposition of amyloid beta peptide, chronic inflammation, and cognitive impairment. The incidence of... -
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- Iron Reshapes the Gut Microbiome and Host Metabolism
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Botta A, Barra NG, Lam NH, Chow S, Pantopoulos K, Schertzer JD, Sweeney G
- KMID: 2516885
- J Lipid Atheroscler.
- 2021 May;10(2):160-183.
- doi: 10.12997/jla.2021.10.2.160
Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including... -
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- Crosstalk between the heart and peripheral organs in heart failure
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Jahng JW, Song E, Sweeney G
- KMID: 2361504
- Exp Mol Med.
- 2016 Mar;48(3):e217.
- doi: 10.1038/emm.2016.20
Mediators from peripheral tissues can influence the development and progression of heart failure (HF). For example, in obesity, an altered profile of adipokines secreted from adipose tissue increases the incidence... -
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