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A Case of Colonic Mucinous Adenocarcinoma in 19-year-old Male Patient

Chung MY, Park YS, Ryu SR, Ahn SB, Kim SH, Jo YJ, Han JK, Joo JE

Colorectal cancer is rare in teenagers, especially without known risk factors. Colon cancer in young age is more likely to be diagnosed at advanced-stage, to present unfavorable tumor histology such...
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Clinicopathologic Features of Sporadic Colorectal Cancer with MLH1/MSH2 Loss of Expression - Reduced Likelihood of Metastases

Park JW, Chang HJ, Jung KH, Kim DY, Sohn DK, Han KS, Hong CW, Lim SB, Choi HS, Jeong SY, Lee SJ

PURPOSE: This study was designed to determine the frequency of MMR defective sporadic colorectal cancer (CRC) by using immunohistochemistry and to investigate the correlation between the MMR status and the...
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Efficacy of hMLH1/hMSH2 Immunohistochemical Staining as Representative Index for Microsatellite Instability Status in Sporadic Colorectal Cancer

Jung SH, Kim HC, Kim JS, Choi J, Yu CS, Kim JC

  • KMID: 2199241
  • J Korean Soc Coloproctol.
  • 2006 Jun;22(3):184-191.
PURPOSE: Sporadic colorectal cancer with micosatellite instability (MSI) is supposed to have a distinct molecular profile, distinct clinocopathologic feature, and a distinct prognosis. However, the test for MSI is still...
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Relation between the Low Molecular Weight Cyclin E and Mutator Phenotype in Sporadic Colorectal Cancer

Park DG

  • KMID: 1940535
  • J Korean Surg Soc.
  • 2005 Sep;69(3):224-230.
PURPOSE: Cyclin E/CDK2 complexes are thought to play critical roles in multiple cell cycle events, including DNA replication, centrosome duplication, and activation of the E2F transcriptional program. Deregulation of the...
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Clinicopathological Characteristics of Sporadic Colorectal Cancer with DNA Microsatellite Instability

Kim NK, Kim H, Park JK, Lee KY, Sohn SK, Min JS

  • KMID: 1626387
  • J Korean Soc Coloproctol.
  • 2003 Feb;19(1):13-19.
PURPOSE: Sporadic colorectal cancers, with DNA microsatellite instability (MSI), have been characterized by a predilection area of proximal colon, younger age onset, exophytic growth and larger tumor size. MSI colorectal...
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Genetic Instability and Mutations of Mismatch Repair (MMR) and p53 Gene in Colorectal Cancers with Multiple Polyps and Sporadic Colorectal Cancers

Chun SW, Chang SK

  • KMID: 2334284
  • J Korean Soc Coloproctol.
  • 2002 Dec;18(6):353-362.
PURPOSE: General conceptions of carcinogenic mechanisms by recent reports are ras-p53 gene pathway in sporadic colorectal cancers (SCC), MMR gene pathway in hereditary nonpolyposis colorectal cancer (HNPCC) and APC gene...
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hMLH1/hMSH2 Protein Expression in Sporadic Colorectal Carcinoma and Its Clinicopathological Significance

Kang JH, Lee KY, Lee KH, Yoon C, Oh SM, Lee JH

  • KMID: 2026051
  • J Korean Soc Coloproctol.
  • 2001 Feb;17(1):38-46.
PURPOSE: DNA replication errors (RERs) in repeated nucleotide sequences (microsatellite instability) is caused by defective mismatch repair (MMR) genes. Ninety percent of colorectal carcinomas in hereditary nonpolyposis colorectal cancer (HNPCC)...
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Microsatellite Instability and hMSH2 Gene Mutations in Sporadic Colorectal Cancers

Jeon HM, Oh ST, Kim JS, Chang SK, Kim JS

  • KMID: 2101319
  • J Korean Soc Coloproctol.
  • 1998 Mar;14(1):41-49.
Microsatellites are short nucleotide repeat sequences present throughout the human genome. Alterations of microsatellites, comprising extra or missing copies of these se quences, have been termed microsatellite instability(MSI, genetic instability,...
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