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Ibrutinib reduces neutrophil infiltration, preserves neural tissue and enhances locomotor recovery in mouse contusion model of spinal cord injury

Torabi S, Anjamrooz SH, Zeraatpisheh Z, Aligholi H, Azari H

Following acute spinal cord injury (SCI), excessive recruitment of neutrophils can result in inflammation, neural tissue loss and exacerbation of neurological outcomes. Ibrutinib is a bruton’s tyrosine kinase inhibitor in...
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Optimal Ratio of Wnt3a Expression in Human Mesenchymal Stem Cells Promotes Axonal Regeneration in Spinal Cord Injured Rat Model

Yoon HH, Lee HJ, Min J, Kim JH, Park JH, Kim JH, Kim SW, Lee H, Jeon SR

Objective : Through our previous clinical trials, the demonstrated therapeutic effects of MSC in chronic spinal cord injury (SCI) were found to be not sufficient. Therefore, the need to develop...
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Effectiveness of Neurodynamic Mobilization versus Conventional Therapy on Spasticity Reduction and Upper Limb Function in Tetraplegic Patients

Saxena A, Sehgal S, Jangra MK

Study Design: The study employed a pre- and post-test experimental design. Purpose: This study was designed to assess the effect of neurodynamic mobilization of the median nerve on upper limb spasticity...
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Should We Delay Urodynamic Study When Patients With Spinal Cord Injury Have Asymptomatic Pyuria?

Kim E, Lee HJ, Kim O, Park IS, Lee BS

Objective To assess the incidence of urinary tract infection (UTI) with post-urodynamic study (post-UDS) in patients with spinal cord injury (SCI) and study its relationship with pre-UDS pyuria. Methods Patients with...
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Impact of Patient Counseling and Socioeconomic Factors on Initiation of Rehabilitation Program in Spinal Cord Injury Patients Presenting to a Tertiary Spine Unit in India

Aiyer SN, Gunasekaran V, Mani L, K. S. SVA, Rajasekaran S, Shetty AP

Study Design Prospective case series. Purpose This study aimed to investigate the impact of education, financial income, occupation, and patient counseling on the timing of enrolment in a spinal cord injury (SCI) rehabilitation...
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Transcranial direct current stimulation for spinal cord injuryassociated neuropathic pain

Li C, Jirachaipitak S, Wrigley P, Xu H, Euasobhon P

Several types of pain occur following spinal cord injury (SCI); however, neuropathic pain (NP) is one of the most intractable. Invasive and non-invasive brain stimulation techniques have been studied in...
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Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain

Hosseini M, Parviz M, Shabanzadeh AP, Zamani E

Study Design: In this study, we decided to change the activity of periaqueductal gray (PAG)'s metabotropic glutamate receptors subtype 8 (mGluR8) by means of its specific agonist, (S)-3,4-dicarboxyphenylglycine (DCPG), and...
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Epidemiology of Spinal Cord Injury: Changes to Its Cause Amid Aging Population, a Single Center Study

Kim HS, Lim KB, Kim J, Kang J, Lee H, Lee SW, Yoo J

Objective To investigate the epidemiologic and demographic characteristics of patients with spinal cord injury (SCI) who were admitted to a department of rehabilitation of a university hospital. Methods This was a...
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Correlation Between Duration From Injury and Bone Mineral Density in Individuals With Spinal Cord Injury

Choi H, Chang Sy, Yoo J, Lim SH, Hong BY, Kim JS

Objective To investigate the correlation between bone mineral density (BMD) and duration of injury in individuals with spinal cord injury (SCI). Methods Patients with SCI who visited the outpatient department between...
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Development and Evaluation of the Korean Version of Hospital-Based Transitional Rehabilitation Program Using Daily Living Home for Spinal Cord Injury

Moon CW, Jung IY, Kim JY, Jang HN, Cho KH

Objective To develop and evaluate the Korean version of a hospital-based transitional rehabilitation program (TRP), using daily living home for spinal cord injury (SCI) patients. Methods In this study, we developed...
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Charcot Spinal Arthropathy with Extensive Vertebral BodyDestruction and Cerebrospinal Fluid Collection:A Case Report Mimicking Infective Spondylitis

Cho KJ, Kim YJ, Kim YT, Youn YH

A 68-year-old man presented with a bed sore with pus discharge on lower back. Radiographs showed extensive destruction of the L4vertebral body. Magnetic resonance imaging (MRI) showed fluid collection with...
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A Fully Immersive Virtual Reality Method for Upper Limb Rehabilitation in Spinal Cord Injury

Lim DY, Hwang DM, Cho KH, Moon CW, Ahn SY

Objective To determine whether a fully immersive virtual reality (VR) intervention combined with conventional rehabilitation (CR) can improve upper limb function more than CR alone in patients with spinal cord...
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Changes in the Trend in Bladder Emptying Methods in Patients With Spinal Cord Injury: A 20-Year Single-Center Retrospective Study

Oh SW, Jung JH, Cho IK, Lee HJ, Kwon SH, Lee BS

Objective To review trends in bladder emptying methods over a 20-year period in patients with spinal cord injury (SCI) by severity according to the American Spinal Injury Association impairment scale...
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Venous Thromboembolism Chemoprophylaxis Within 24 Hours of Surgery for Spinal Cord Injury: Is It Safe and Effective?

Ahlquist S, Park HY, Kelley B, Holly L, Shamie AN, Park DY

Objective: Current guidelines recommend initiation of venous thromboembolism (VTE) chemoprophylaxis within 72 hours of spinal cord injury (SCI). This study investigated the safety and efficacy of chemoprophylaxis within 24 hours...
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Recovery without neurological sequelae of traumatic spinal epidural hematoma masquerading as Guillain-Barré syndrome in a child

Lee JS, Kim DH, Kwon YS

Spinal cord lesions could mimic Guillain-Barré syndrome (GBS). Misdiagnosis as GBS can incur severe neurologic sequelae. We report the case of a previously healthy, 14-year-old boy with traumatic spinal epidural...
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Energy Efficiency and Patient Satisfaction of Gait With Knee-Ankle-Foot Orthosis and Robot (ReWalk)-Assisted Gait in Patients With Spinal Cord Injury

Kwon SH, Lee BS, Lee HJ, Kim EJ, Lee JA, Yang SP, Kim TY, Pak HR, Kim HK, Kim HY, Jung JH, Oh SW

Objective To compare the energy efficiency of gait with knee-ankle-foot orthosis (KAFO) and robot-assisted gait and to develop a usability questionnaire to evaluate the satisfaction of walking devices in paraplegic...
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The Therapeutic Potential of Conditioned Medium from Human Breast Milk Stem Cells in Treating Spinal Cord Injury

Borhani-Haghighi M, Navid S, Mohamadi Y

Study Design: Experimental animal study. Purpose: This study investigated the therapeutic effects of human breast milk stem cell (BMSC)-conditioned medium (BMSC-CM) in a model of spinal cord injury (SCI) in male...
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Current Status and Future Strategies to Treat Spinal Cord Injury with Adult Stem Cells

Jeong SK, Choi I, Jeon SR

Spinal cord injury (SCI) is one of the most devastating conditions and many SCI patients suffer neurological sequelae. Stem cell therapies are expected to be beneficial for many patients with...
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Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury

Thakkar P, Prakash NB, Tharion G, Shetty S, Paul TV, Bondu J, Yadav B

Study Design: Prospective observational study. Purpose: To evaluate bone turnover markers (BTMs) in individuals with acute spinal cord injury (SCI) and to compare the results with those of healthy controls and...
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Role of Virtual Reality in Balance Training in Patients with Spinal Cord Injury: A Prospective Comparative Pre-Post Study

Sengupta M, Gupta A, Khanna M, Krishnan U, Chakrabarti D

Study Design: Prospective comparative pre–post study. Purpose: To evaluate the effects of game-based virtual reality (VR) training program for trunk postural control and balance in patients with spinal cord injury (SCI)...
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