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Suppressive Effect of CYM50358 S1P4 Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice

Jeon WJ, Chung KW, Lee JH, Im DS

Levels of sphingosine 1-phosphate (S1P), an intercellular signaling molecule, reportedly increase in the bronchoalveolar lavage fluids of patients with asthma. Although the type 4 S1P receptor, S1P4 has been detected...
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Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

Song JH, Kim GT, Park KH, Park WJ, Park TS

  • KMID: 2517155
  • Biomol Ther.
  • 2021 Jul;29(4):373-383.
Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover,...
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Topical Application of S1P2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

Kang J, Lee JH, Im DS

Sphingosine-1-phosphate (S1P) and its receptors have been implicated in atopic dermatitis. S1P2 was found to function as a proallergic receptor, while its antagonist JTE-013 was found to suppress allergic asthma...
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Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis

Park SJ, Im DS

Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of...
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Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation

Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY

BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current...
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Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery

Park SJ, Im DS

Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G...
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Sphingolipids and Antimicrobial Peptides: Function and Roles in Atopic Dermatitis

Park K, Lee S, Lee YM

  • KMID: 2170669
  • Biomol Ther.
  • 2013 Jul;21(4):251-257.
Inflammatory skin diseases such as atopic dermatitis (AD) and rosacea were complicated by barrier abrogation and deficiency in innate immunity. The first defender of epidermal innate immune response is the...
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Association of Bone Marrow Sphingosine 1-phosphate Levels with Osteoporotic Hip Fractures

Ahn SH, Koh JM, Gong EJ, Byun S, Lee SY, Kim BJ, Lee SH, Chang JS, Kim GS

BACKGROUND: Sphingosine 1-phosphate (S1P) has been discovered to be a critical regulator of bone metabolism. Very recently, we found that higher circulating S1P levels were associated with higher rate of...
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Prolonged ERK Activation of S1P on B16 Melanoma Cells

Lee HS, Choi GS, Shin JH

  • KMID: 2248133
  • Korean J Dermatol.
  • 2008 Jun;46(6):769-775.
BACKGROUND: The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), was reported to induce apoptosis of some cancer cells and neurons, although it is generally known to exert mitogenic and antiapoptotic effects....
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Sphingosine 1-Phosphate Triggers Apoptotic Signal for B16 Melanoma Cells via ERK and Caspase Activation

Shin JH, Choi GS, Kang WH, Myung KB

The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In...
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FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation

Brinkmann

FTY720 is a novel immunomodulator that has proven effective in animal models of transplantation and autoimmunity, has achieved promising results in Phase I and Phase II studies of renal transplantation...
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Analysis of a Sphingosine 1-phosphate Receptor hS1P3 in Rat Hepatoma Cells

Im DS

  • KMID: 2285242
  • Korean J Physiol Pharmacol.
  • 2002 Jun;6(3):139-142.
To examine intracellular signaling of human S1P3 (hS1P3), a sphingosine 1-phosphate (S1P) receptor in plasma membrane, hS1P3 DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of...
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