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Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells

Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS

  • KMID: 1123762
  • Exp Mol Med.
  • 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),...
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