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Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

So I, Ashmole I, Soh H, Park C, Spencer P, Leyland M, Stanfield

  • KMID: 2071587
  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):131-142.
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or...
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