- Report of the Korean Association of External Quality Assessment Service on Next-Generation Sequencing Analysis for Somatic Variants (2018–2020)
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Kim H, Won D, Shin S, Lee ST, Choi JR
- KMID: 2517260
- Lab Med Qual Assur.
- 2021 Jun;43(2):65-71.
- doi: 10.15263/jlmqa.2021.43.2.65
Next-generation sequencing is widely used to detect a variety of genetic defects in many disorders. The detection of somatic variants in patients with cancer, including hematologic malignancy, is important for... -
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- Development of a Method for Manufacturing External Quality Assessment Material for Genetic Testing of Solid Tumors Using Mutant and Wild-Type Cell Lines
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Hong J, Kim JH, Park S, Lee SG, Lee W, Chun S, Min WK
- KMID: 2514599
- Lab Med Qual Assur.
- 2021 Mar;43(1):31-36.
- doi: 10.15263/jlmqa.2021.43.1.31
Background: DNA extracted from mutant cell lines is frequently used as an external quality assessment (EQA) material for genetic testing of solid tumors because it is easy to obtain. However,... -
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- Korean Society for Genetic Diagnostics Guidelines for Validation of Next-Generation Sequencing-Based Somatic Variant Detection in Hematologic Malignancies
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Kim H, Yun JW, Lee ST, Kim HJ, Kim SH, Kim JW, The Korean Society for Genetic Diagnostics Clinical Guidelines Committee
- KMID: 2450945
- Ann Lab Med.
- 2019 Nov;39(6):515-523.
- doi: 10.3343/alm.2019.39.6.515
Next-generation sequencing (NGS) is currently used in the clinical setting for targeted therapies and diagnosis of hematologic malignancies. Accurate detection of somatic variants is challenging because of tumor purity, heterogeneity,... -
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