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The Safety and Efficacy of Anakinra, an Interleukin-1 Antagonist in Severe Cases of COVID-19: A Systematic Review and Meta-Analysis

Somagutta MKR, Pormento MKL, Hamid P, Hamdan A, Khan MA, Desir R, Vijayan R, Shirke S, Jeyakumar R, Dogar Z, Makkar SS, Guntipalli P, Ngardig NN, Nagineni MS, Paul T, Luvsannyam E, Riddick C, Sanchez-Gonzalez MA

This study aims to assess anakinra's safety and efficacy for treating severe coronavirus disease 2019 (COVID-19). Numerous electronic databases were searched and finally 15 studies with a total of 3,530...
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Dietary Changes Leading to Euglycemic Diabetic Ketoacidosis in Sodium-Glucose Cotransporter-2 Inhibitor Users: A Challenge for Primary Care Physicians?

Somagutta MKR, Uday U, Shama N, Bathula NR, Pendyala S, Mahadevaiah A, Mahmutaj G, Ngardig NN

Background: The use of euglycemic diabetic ketoacidosis (EDKA) related to sodium-glucose cotransporter 2 inhibitors (SGLT2i) use in people with diabetes has been increasingly reported. The causes are multifactorial, and dietary...
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The Efficacy of vitamin C, thiamine, and corticosteroid therapy in adult sepsis patients: a systematic review and meta-analysis

Somagutta MKR, Pormento MKL, Khan MA, Hamdan A, Hange N, KC M, Pagad S, Jain MS, Lingarajah S, Sharma V, Kaur J, Emuze B, Batti E, Iloeje OJ

Background: Previous studies have suggested favorable outcomes of hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT) therapy in patients with sepsis. However, similar results have not been duplicated in sequential...
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