- Relationship between the Expression of Sodium Iodide Symporter and the Findings of 99mTc-MIBI Scintimammography in the Primary Breast Cancer
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Seok JW, Kim SJ, Kwak HS, Lee CH, Kim IJ, Kim YK, Bae YT, Kim DS
- KMID: 1614101
- Korean J Nucl Med.
- 2002 Dec;36(6):325-332.
No abstract available. -
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- Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma
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Chung JK, Kim HW, Youn H, Cheon GJ
- KMID: 2422792
- Nucl Med Mol Imaging.
- 2018 Oct;52(5):325-326.
- doi: 10.1007/s13139-018-0540-y
Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide... -
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- Sodium Iodide Symporter and the Radioiodine Treatment of Thyroid Carcinoma
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Chung JK, Youn HW, Kang JH, Lee HY, Kang KW
- KMID: 2051960
- Nucl Med Mol Imaging.
- 2010 Apr;44(1):4-14.
Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of... -
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- Updates of Radioiodine Treatment for Graves' Disease
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Jeong SY
- KMID: 2465060
- Int J Thyroidol.
- 2019 Nov;12(2):85-90.
- doi: 10.11106/ijt.2019.12.2.85
Radioiodine (RAI) has been used for the treatment of hyperthyroidism and is usually administered orally as sodium iodide (I-131) in solution or a capsule. However, this results in RAI being... -
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- Expression of Human Sodium Iodide Symporter mRNA in Papillary Thyroid Carcinoma
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Kim HK, Ahn IM, Kim YI, Kim ES, Park HS, Park KY, Hong SJ
- KMID: 2142204
- J Korean Soc Endocrinol.
- 1998 Jun;13(2):181-188.
BACKGROUND: The sodium iodide symporter(NIS) is a plasma membrane protein which is respoasibIe for iodide transport into thyroid cell. The cDNA sequence of NIS has recently been cloned from rat... -
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- Effect of LiCl on Iodine Kinetics in Thyroid Cancer Cell Lines Transduced by Recombinant Adenovirus Containing Sodium Iodide Symporter(NIS) Gene
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Kim WB, Song JY, Han SM, Yeo JS, Lee HR, Shong YK, Moon DH
- KMID: 2331172
- J Korean Soc Endocrinol.
- 2003 Apr;18(2):166-176.
BACKGROUND: Lithium is known to increase the retention of iodide in the thyroid gland, or in well differentiated thyroid cancer tissue. The effects of lithium on the function of the... -
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- Sunitinib-induced hypothyroidism
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Kim SW
- KMID: 2257384
- Korean J Med.
- 2009 Jan;76(1):33-36.
Sunitinib malate is a multi-targeted tyrosine kinase inhibitor used for gastrointestinal stromal tumor and renal cell carcinoma. It is also under phase II trial for use in advanced colon cancer,... -
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- Iododerma Following Radioactive Iodine Ablation of the Thyroid for Thyroid Cancer
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Suh KS, Park JB, Han SH, Kim ST, Jang MS
- KMID: 2038554
- Korean J Dermatol.
- 2013 Jan;51(1):53-56.
Iododerma is a rare cutaneous eruption that occurs after oral, parenteral or topical administration of iodides. Acneiform papulopustular lesions are the most common skin reactions of iododerma and erythematous, vesiculobullous,... -
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- Clinical Significance of Human Sodium Iodide Symporter mRNA Expressions in Primary and Metastatic Papillary Thyroid Carcinoma
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Lee SJ, Park HJ, Lee EJ, Kim HY, Koh JK, Park KY, Kim SB, Gong GY, Hong SJ, Ahn IM, Kim SH
- KMID: 2199508
- J Korean Soc Endocrinol.
- 1999 Sep;14(3):514-519.
BACKGROUND: The iodide transport into thyroid cells is an essential step in the biosynthesis of thyroid hormones. The sodium iodide symporter (NIS) which is responsible for iodide transport was cloned... -
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- Radioactive Iodine-Refractory Differentiated Thyroid Cancer and Redifferentiation Therapy
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Liu J, Liu Y, Lin Y, Liang J
- KMID: 2458623
- Endocrinol Metab.
- 2019 Sep;34(3):215-225.
- doi: 10.3803/EnM.2019.34.3.215
The retained functionality of the sodium iodide symporter (NIS) expressed in differentiated thyroid cancer (DTC) cells allows the further utilization of post-surgical radioactive iodine (RAI) therapy, which is an effective... -
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- RAI Treatment of Distant Metastasis of Thyroid Cancer
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Kang KW
- KMID: 1428453
- J Korean Thyroid Assoc.
- 2013 May;6(1):49-55.
- doi: 10.11106/jkta.2013.6.1.49
For the distant metastasis of differentiated thyroid cancers, such as papillary thyroid carcinoma, follicular thyroid carcinoma, and Hurthle cell carcinoma, radioiodine therapy is one of the standard treatment methods after... -
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- Molecular Imaging Using Sodium Iodide Symporter (NIS)
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Cho JY
- KMID: 2078807
- Korean J Nucl Med.
- 2004 Apr;38(2):152-160.
Radioiodide uptake in thyroid follicular epithelial cells, mediated by a plasma membrane transporter, sodium iodide symporter (NIS), provides a first step mechanism for thyroid cancer detection by radioiodide injection and... -
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- Comparison of Human Sodium/Iodide Symporter (hNIS) Gene Expressions between Lentiviral and Adenoviral Vectors in Rat Mesenchymal Stem Cells
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Park SY, Kim SJ, Lee WW, Lee H, Kim HJ, Chung JK, Kim SE
- KMID: 2051952
- Nucl Med Mol Imaging.
- 2008 Oct;42(5):394-400.
PURPOSE: Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirus-mediated delivery systems has not been reported. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression... -
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- Development of Dual Reporter System of Mutant Dopamine 2 Receptor (D2R) and Sodium Iodide Symporter (NIS) Transgenes
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Hwang DW, Lee DS, Kang JH, Chang YS, Kim YH, Jeong JM, Chung JK, Lee MC
- KMID: 1990860
- Korean J Nucl Med.
- 2004 Aug;38(4):294-299.
PURPOSE: Both human NIS and mutant D2R transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide... -
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- Sodium Iodide Symporter and Phosphatase and Tensin Homolog Deleted on Chromosome Ten Expression in Cholangiocarcinoma Analysis with Clinicopathological Parameters
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Kim JH, Han SY, Lee SW, Baek YH, Kim HY, Kim JH, Jeong JS, Roh YH, Kim YH, Park BH, Kwon HJ, Cho JH, Nam KJ
- KMID: 2053502
- Gut Liver.
- 2012 Jul;6(3):374-380.
BACKGROUND/AIMS: This study was performed to investigate the correlation of sodium iodide symporter (NIS) expression with the functionality and loss of phosphatase and tensin homolog deleted on chromosome ten (PTEN)... -
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- The Effect of Tanespimycin (17-AAG) on Radioiodine Accumulation in Sodium-Iodide Symporter Expressing Cells
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Yu KH, Youn H, Song MG, Lee DS, Chung JK
- KMID: 1427732
- Nucl Med Mol Imaging.
- 2012 Dec;46(4):239-246.
PURPOSE: The heat shock protein 90 inhibitor, tanespimycin, is an anticancer agent known to increase iodine accumulation in normal and cancerous thyroid cells. Iodine accumulation is regulated by membrane proteins... -
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- Enhanced Effect of Iodide - Uptake in Thyroid Carcinoma Cells by Infecting Adenovirus - Human Sodium Iodide Symporter (Ad - hNIS)
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Park KK, Jin JS, Lee SJ, Park JY, Lee HR, Moon DH, Ahn IM, Chang HS
- KMID: 2199730
- J Korean Soc Endocrinol.
- 2000 Oct;15(4-5):522-531.
BACKGROUND: The sodium-iodide-symporter (NIS) is a plasma membrane glycoprotein with 13 putative transmembrane domains, which is responsible for concentrating iodide into the thyroid by an active transport and provides the... -
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- Bilateral Renal Metastasis of Hürthle Cell Thyroid Cancer with Discordant Uptake Between I-131 Sodium Iodide and F-18 FDG
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Claimon A, Suh M, Cheon GJ, Lee DS, Kim EE, Chung JK
- KMID: 2396585
- Nucl Med Mol Imaging.
- 2017 Sep;51(3):256-260.
- doi: 10.1007/s13139-016-0462-5
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The... -
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- In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression
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Kim KI, Lee YJ, Lee TS, Song I, Cheon GJ, Lim SM, Chung JK, Kang JH
- KMID: 1427701
- Nucl Med Mol Imaging.
- 2013 Mar;47(1):1-8.
PURPOSE: This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha-fetoprotein (AFP)-producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human... -
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- Radioiodine Therapy of Liver Cancer Cell Following Tissue Specific Sodium Iodide Symporter Gene Transfer and Assessment of Therapeutic Efficacy with Optical Imaging
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Jang BK, Lee YL, Lee YJ, Ahn SJ, Ryu MJ, Yoon SM, Lee SW, Yoo J, Cho JY, Lee J, Ahn BC
- KMID: 2051951
- Nucl Med Mol Imaging.
- 2008 Oct;42(5):383-393.
PURPOSE: Cancer specific killing can be achieved by therapeutic gene activated by cancer specific promotor. Expression of sodium iodide symporter (NIS) gene causes transportation and concentration ofiodide into the cell,... -
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