- 4-1BB (CD137) signals depend upon CD28 signals in alloimmune responses
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Lee EA, Kim JE, Seo JH, Kwon BS, Nam SH, Kwon B, Cho HR
- KMID: 1115938
- Exp Mol Med.
- 2006 Dec;38(6):606-615.
Our previous study has demonstrated that there is a significant delay of Balb/c cardiac allograft rejection in the C57BL/6 4-1BB-deficient knockout recipient. In this study, we examined the effect of... -
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- Negative regulatory approaches to the attenuation of Toll-like receptor signaling
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Anwar MA, Basith S, Choi S
- KMID: 2154230
- Exp Mol Med.
- 2013 Feb;45(2):e11.
Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is responsible for eradicating invading microorganisms through the induction of inflammatory molecules. These receptors are also involved in... -
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- IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model
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Kim YS, Choi SJ, Choi JP, Jeon SG, Oh SY, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK
- KMID: 1104380
- Exp Mol Med.
- 2010 Aug;42(8):533-546.
- doi: 10.3858/emm.2010.42.8.054
IL-4 and IL-13 are closely related cytokines that are produced by Th2 cells. However, IL-4 and IL-13 have different effects on the development of asthma phenotypes. Here, we evaluated downstream... -
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