- Increasing the alpha 2, 6 Sialylation of Glycoproteins May Contribute to Metastatic Spread and Therapeutic Resistance in Colorectal Cancer
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Park JJ, Lee M
- KMID: 1712321
- Gut Liver.
- 2013 Nov;7(6):629-641.
Abnormal glycosylation due to dysregulated glycosyltransferases and glycosidases is a key phenomenon of many malignancies, including colorectal cancer (CRC). In particular, increased ST6 Gal I (beta-galactoside alpha 2, 6 sialyltransferase)... -
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- Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid-Associated Ophthalmopathy
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Park HJ, Kim JH, Yoon JS, Choi YJ, Choi YH, Kook KH, Choi JH
- KMID: 2418898
- Yonsei Med J.
- 2017 Nov;58(6):1160-1169.
- doi: 10.3349/ymj.2017.58.6.1160
PURPOSE: This study was conducted to identify and to functionally characterize genetic variants in ST3GAL5 and ST8SIA1 in Korean patients with thyroid-associated ophthalmopathy (TAO). MATERIALS AND METHODS: Genetic analyses were conducted... -
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- A clinicopathologic study on the diffuse malignant lymphoma: a morphologic and immunophenotypic analysis in 62 patients at Harbor-UCLA Medical Center
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Lee JH, Sun NC, Salahi W, Chen H, Yang MH
- KMID: 1421916
- J Korean Med Sci.
- 1992 Sep;7(3):204-313.
- doi: 10.3346/jkms.1992.7.3.204
In order to compare the prognoses of patients with diffuse malignant lymphomas on the basis of histology and immunophenotypes, we retrospectively studied 62 cases of diffuse lymphoma arising in... -
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- Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells
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Kwon HY, Kim SJ, Kim CH, Son SW, Kim KS, Lee JH, Do SI, Lee YC
- KMID: 1115269
- Exp Mol Med.
- 2010 Dec;42(12):849-855.
- doi: 10.3858/emm.2010.42.12.088
In this study, we have shown that gene expression of human GD3 synthase (hST8Sia I) is suppressed by triptolide (TPL) in human melanoma SK-MEL-2 cells. To elucidate the mechanism underlying... -
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- GD3 Accumulation in Cell Surface Lipid Rafts Prior to Mitochondrial Targeting Contributes to Amyloid-beta-induced Apoptosis
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Kim JK, Kim SH, Cho HY, Shin HS, Sung HR, Jung JR, Quan ML, Jiang DH, Bae HR
- KMID: 2157855
- J Korean Med Sci.
- 2010 Oct;25(10):1492-1498.
- doi: 10.3346/jkms.2010.25.10.1492
Neuronal apoptosis induced by amyloid beta-peptide (A beta) plays an important role in the pathophysiology of Alzheimer's disease (AD). However, the molecular mechanism underlying A beta-induced apoptosis remains undetermined. The... -
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