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Correspondence on Editorial regarding “HBV pgRNA and HBcrAg reductions at week 4 predict favourable HBsAg response upon long-term nucleos(t)ide analogue in CHB”

Mak LY, Seto WK, Yuen MF

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Correspondence on Letter regarding “COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis”

Cheung KS, Mok CH, Seto WK, Yuen MF

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Functional cure of chronic hepatitis B encounters resmetirom

Yang NB, Seto WK, Zheng MH

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Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer

Lam YF, Seto WK, Tong T, Cheung KS, Lo O, Hung IF, Law WL, Leung WK

BACKGROUND/AIMS: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. METHODS: Consecutive CRC patients who had undergone surgical...
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Screening strategy for non-alcoholic fatty liver disease

Zhang S, Mak LY, Yuen MF, Seto WK

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting approximately 25% of the general population worldwide, and is forecasted to increase global health burden in the...
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The role of different viral biomarkers on the management of chronic hepatitis B

Mak LY, Hui RWH, Fung J, Seto WK, Yuen MF

Chronic hepatitis B infection is a major public health challenge. With the advancement in technology, various components of the viral cycle can now be measured in the blood to assess...
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Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region

Zhu RX, Seto WK, Lai CL, Yuen MF

Hepatocellular carcinoma (HCC) is the predominant primary liver cancer in many countries and is the third most common cause of cancer-related death in the Asia-Pacific region. The incidence of HCC...
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RNA interference as a novel treatment strategy for chronic hepatitis B infection

Hui RWH, Mak LY, Seto WK, Yuen MF

Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality. Functional cure of CHB, defined as sustainable hepatitis B surface antigen (HBsAg) seroclearance, is associated with improved...
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New Biomarkers of Chronic Hepatitis B

Mak LY, Seto WK, Fung J, Yuen MF

Chronic hepatitis B (CHB) infection leads to clinically heterogeneous disease outcomes. Different viral markers are utilized to monitor treatment effects and predict risk of complications in patients with CHB. Hepatitis...
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Clinical practice guidelines and real-life practice on hepatocellular carcinoma: the Hong Kong perspective

Hui RWH, Mak LY, Cheung TT, Lee VHF, Seto WK, Yuen MF

Hepatocellular carcinoma (HCC) is a major public health burden in Hong Kong, and chronic hepatitis B is the most common HCC etiology in our region. With the high case load,...
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Long-term Hepatitis B Surface Antigen Profile and Seroclearance after Severe Acute Flares of Chronic Hepatitis B

Hui KY, Fung J, Cheung KS, Mak LY, Seto WK, Yuen MF

Background/Aims: Hepatitis B surface antigen (HBsAg) seroclearance remains uncommon in chronic hepatitis B (CHB) infection. During acute flares of CHB (AFOCHB), alanine aminotransferase elevation reflects a mounting immune response toward...
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Entecavir Reduced Serum Hepatitis B Core-Related Antigen in Chronic Hepatitis B Patients with Hepatocellular Carcinoma

Mak LY, Ko KL, To WP, Wong DKH, Seto WK, Fung J, Yuen MF

Serum hepatitis B core-related antigen (HBcrAg) was shown to predict the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients undergoing treatment. We investigated the longitudinal profile of...
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COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis

Cheung KS, Mok CH, Mao X, Zhang R, Hung IF, Seto WK, Yuen MF

Background/Aims: Data of coronavirus disease 2019 (COVID-19) vaccine immunogenicity among chronic liver disease (CLD) and liver transplant (LT) patients are conflicting. We performed meta-analysis to examine vaccine immunogenicity regarding etiology,...
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Development of a Non-Invasive Liver Fibrosis Score Based on Transient Elastography for Risk Stratification in Patients with Type 2 Diabetes

Lee CH, Seto WK, Ieong K, Lui DT, Fong CH, Wan HY, Chow WS, Woo YC, Yuen MF, Lam KS

Background: In non-alcoholic fatty liver disease (NAFLD), transient elastography (TE) is an accurate non-invasive method to identify patients at risk of advanced fibrosis (AF). We developed a diabetes-specific, non-invasive liver...
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Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients

Cheung KS, Lam LK, Hui RWH, Mao X, Zhang RR, Chan KH, Hung IF, Seto WK, Yuen MF

Background/Aims: Studies of hepatic steatosis (HS) effect on COVID-19 vaccine immunogenicity are lacking. We aimed to compare immunogenicity of BNT162b2 and CoronaVac among moderate/severe HS and control subjects. Methods: Two hundred...
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Hepatitis B virus pre-genomic RNA and hepatitis B core-related antigen reductions at week 4 predict favourable hepatitis B surface antigen response upon long-term nucleos(t)ide analogue in chronic hepatitis B

Mak LY, Wong D, Kuchta A, Hilfiker M, Hamilton A, Chow N, Mao X, Seto WK, Yuen MF

Background/Aims: We investigated the dynamics of serum HBV pre-genomic RNA (pgRNA) and hepatitis B core-related antigen (HBcrAg) in patients receiving nucleos(t)ide analogues (NAs) and their predictability for favourable suppression of...
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