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5-HT1A Partial Agonist Tandospirone for Behavioral and Psychological Symptoms in Oldest-old Patients with Dementia at a Special Elderly Nursing Home

Ochi S, Mori T, Iga Ji, Ueno Si

Objective: To investigate the efficacy of tandospirone, an azapirone anxiolytic similar to buspirone that is used in Japan, for behavioral and psychological symptoms of dementia (BPSD), especially in oldest-old patients. Methods:...
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The Role of Serotonin in Ventricular Repolarization in Pregnant Mice

Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B

PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role...
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Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway

Afzal R, Shim WS

Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger...
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Ondansetron Inhibits Voltage-Gated K⁺ Current of Ventricular Myocytes from Pregnant Mouse

Cui S, Park H, Park H, Mun D, Kim HE, Yun N, Joung B

BACKGROUND: The Htr3a antagonist, ondansetron, has been reported to prolong the QT interval and induce Torsades de pointes in the treatment of postoperative nausea and vomiting. To explore the mechanisms...
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Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips

Hattori T, Lluel P, Rouget C, Rekik M, Yoshiyama

PURPOSE: The aim of this study was to assess the potential involvement of a specific subtype of 5-hydroxytryptamine (5-HT), 5HT(2) receptors in neurally-induced contractions of the human detrusor. METHODS: Contractile responses...
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Associations between Serotonergic Genes and Escitalopram Treatment Responses in Patients with Depressive Disorder and Acute Coronary Syndrome: The EsDEPACS Study

Kang HJ, Bae KY, Kim SW, Shin IS, Hong YJ, Ahn Y, Jeong MH, Park SW, Kim YH, Yoon JS, Kim JM

Genes related to serotonin are associated with responses to treatment for depression. We examined associations between the serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes and responses to treatment...
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Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat

Lin H, Lee HG, Yoon MH

  • KMID: 1797467
  • Anesth Pain Med.
  • 2014 Apr;9(2):93-97.
BACKGROUND: Tianeptine is an antidepressant drug which is used for treating depression. Interestingly, the tianeptine has shown antinociceptive effects within a variety of nociceptions. The aim of this study is...
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Effects of Genetic and Environmental Factors on the Depression in Early Adulthood

Kim SK, Lee SI, Shin CJ, Son JW, Eom SY, Kim H

  • KMID: 1770031
  • Korean J Biol Psychiatry.
  • 2008 Feb;15(1):14-22.
OBJECTIVES: The authors purposed to present data for explaining gene-environmental interaction causing depressive disorder by examining the effects of genetic factors related to the serotonin system and environmental factors such...
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Association Study between 5-HT2A Receptor and DRD3 Receptor Gene Polymorphism and Clinical Response to Atypical Antipsychotics in Patients with Schizophrenia

Kim BS, Joo YH, Kim CY, Park JH, Song KY, Han OS

  • KMID: 2340671
  • J Korean Neuropsychiatr Assoc.
  • 2002 May;41(3):409-420.
OBJECTIVES: This study was performed based on the hypothesis that the interindividual differences in clinical response to atypical antipsychotics might be associated with serotonin 2A receptor(5-HT2A) gene and(or) dopamine D3...
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Serotonin in Psychiatry

Yang BH

  • KMID: 2202975
  • J Korean Soc Biol Psychiatry.
  • 1997 Nov;4(2):155-161.
Serotonin has been implicated in the etiology of many disease states and may be particularly mental illness, such as depression, anxiety, schizophrenia, sleep disorders, suicide, eating disorders, obsessive compulsive disorders,...
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Distribution of Serotonin-2 Receptor in the Superior Collicullus of the Adult Rat: A Radioarutographic Study

Lee NK, Kim MH, Ahn CB

  • KMID: 2123146
  • J Korean Ophthalmol Soc.
  • 1993 Dec;34(12):1262-1268.
The superior colliculus is a laminated structure that consisted with superficial and deep layers in the roof of midbrain and the center of visual information and sensorimotor intergration. The deep...
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