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Nasal Colonization of Serine Protease esp Positive Staphylococcus epidermidis Affecting Staphylococcus aureus Colonization

Kang G, Kim HS, Kim HS, Song W, Kim JS

Background: Staphylococcus aureus is a common colonizer of the nasal vestibule and is found in approximately 20%–30% of healthy adults, while Staphylococcus epidermidis appears to be the most frequent colonizer...
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Vacuolar Serine Protease Is a Major Allergen of Fusarium proliferatum and an IgE-Cross Reactive Pan-Fungal Allergen

Yeh CC, Tai HY, Chou H, Wu KG, Shen HD

PURPOSE: Fusarium species are among prevalent airborne fungi and causative agents of human respiratory atopic disorders. We previously identified a 36.5-kDa F. proliferatum component recognized by IgE antibodies in 9...
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Serine Proteases of Parasitic Helminths

Yang Y, Wen YJ, Cai YN, Vallee I, Boireau P, Liu MY, Cheng SP

Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion,...
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Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis

Yuan B, Zhou S, Lu Y, Liu J, Jin X, Wan H, Wang F

BACKGROUND/AIMS: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction. METHODS: Rats were fed 4% with dextran sodium sulfate (DSS) to induce experimental colitis. We analyzed...
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Epidermal Proteinase-Activated Receptor-2 Expression is Increased in End-Stage Renal Disease Patients with Pruritus: A Pilot Study

Moon SJ, Kim HJ, Cho SB, Lee SH, Choi HY, Park HC, Ha SK

Uremic pruritus is a common problem in patients with end-stage renal disease (ESRD), but the underlying mechanisms are not yet fully understood. We aimed to investigate the association between severity...
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The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model

Kim BY, Park HR, Shin JH, Kim SW, Cho JH, Park YJ, Kim SW

PURPOSE: Serine protease inhibitors are involved in immune development, anti-inflammatory mechanisms, and tissue repair. In the present study, the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride (AEBSF) was evaluated...
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Two cases of chronic pancreatitis associated with anomalous pancreaticobiliary ductal union and SPINK1 mutation

Rho ES, Kim E, Koh H, Yoo HW, Lee BH, Kim GH

Chronic pancreatitis is a progressive inflammatory disease resulting from repeated episodes of acute pancreatitis that impair exocrine function and eventually produce endocrine insufficiency. Some causes of chronic pancreatitis appear to...
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Immunoresuscitation Effect on Hemorrhagic Shock-Induced Acute Lung Injury in Rats

Park SH, Lee MJ, Jo KH, Kim YG

  • KMID: 2333112
  • J Korean Soc Emerg Med.
  • 2012 Apr;23(2):270-278.
PURPOSE: Recent studies have indicated that cytokines and inflammatory responses are related to hemorrhagic shock-(HS) induced acute lung injury. Novel, synthetic, broad-acting serine protease inhibitors that protect a wide range...
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Association Analysis of SERPINB5 Polymorphisms with HBV Clearance and HCC Occurrence in a Korean Population

Kim JY, Park TJ, Lee JS, Chun JY, Bae JS, Park BL, Cheong HS, Lee HS, Kim YJ, Shin HD

  • KMID: 2166471
  • Genomics Inform.
  • 2010 Mar;8(1):1-8.
Serpin peptidase inhibitor, Clade B (ovalbumin), Member 5 (SERPINB5), also known as maspin, is a potent tumor suppressor gene. It has correlations with many tumor cells, from pancreas cancer to...
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Clinical Improvement of Atopic Dermatitis by a Topical Cream Containing a Protease-Activated Receptor-2 (PAR-2) Inhibitor 'Pal-KTTKS Peptide'

Lee Y, Kim M, Kong ID, Ryu J, Jang M, Lee C, Choi EH

  • KMID: 2301807
  • Korean J Dermatol.
  • 2010 Nov;48(11):966-974.
BACKGROUND: Serine protease promotes desquamatation of the stratum corneum and this is controlled by serine protease inhibitors (SPI). After disruption of the skin barrier, signals for barrier recovery are started...
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The Comparison of Parathyroid Hormone Degradation Effect by Various Protease Inhibitors in Blood Specimen

Kim YS, Kwon HJ, Lee HK

BACKGROUND: The objective of this study was to evaluate the role of proteases on the degradation of parathyroid hormone (PTH) in blood samples. METHODS: Protease inhibitors with specificity against serine...
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Cloning of a Family of Serine Protease Genes Expressed in German Cockroach(Blattella germanica) and Possibility as Allergens

Lee WY, Kim HB, Park JR, Park SH, Park KW, Ock MS, Yu TH

  • KMID: 2276895
  • Korean J Otorhinolaryngol-Head Neck Surg.
  • 2008 Jun;51(6):528-534.
BACKGROUND AND OBJECTIVES: The serine protease allergens have been known as one of the most important inhalent allergens of insects as well as house dust mites. There is no known...
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SPINK1 N34S Mutation as a Possible Cause of Chronic Pancreatitis in a Patient with Familial Background

Oh HC, Lee TY, Kwon S, Lee SS, Seo DW, Lee SK, Kim MH

  • KMID: 782875
  • Korean J Gastroenterol.
  • 2007 Jun;49(6):384-389.
New insight in the field of chronic pancreatitis was provided by the discovery of protease serine 1 (PRSS1) mutation, inherited by autosomal dominant trait in hereditary pancreatitis. Serine protease inhibior,...
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Purification and Characterization of a Keratinase from a Feather-Degrading Fungus, Aspergillus flavus Strain K-03

Kim JD

  • KMID: 2312534
  • Mycobiology.
  • 2007 Dec;35(4):219-225.
A keratinolytic enzyme secreted by Aspergillus flavus K-03 cultured in feather meal basal medium (FMBM) containing 2% (w/v) chicken feather was purified and characterized. Keratinolytic enzyme secretion was the maximal...
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The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity

Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H

  • KMID: 1105275
  • Exp Mol Med.
  • 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation...
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Cloning and expression of trypsin-encoding cDNA from Blattella germanica and its possibility as an allergen

Ock MS, Kim BJ, Kim SM, Byun KH

In this study, the trypsin gene (bgtryp-1) from the German cockroach, Blattella germanica, was cloned via the immunoscreening of patients with allergies to cockroaches. Nucleotide sequence analysis predicted an 863...
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Purification and characterization of a 33 kDa serine protease from Acanthamoeba lugdunensis KA/E2 isolated from a Korean keratitis patient

Kim HK, Ha YR, Yu HS, Kong HH, Chung DI

In order to evaluate the possible roles of secretory proteases in the pathogenesis of amoebic keratitis, we purified and characterized a serine protease secreted by Acanthamoeba lugdunensis KA/E2, isolated from...
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Phorbol Ester Induced - Apoptosis Mediated by Activating Serine Protease ( s ) and Caspase - 3 / CPP32 in SNU - 16 Human Gastric Cancer Cell Line

Park IC, Park MJ, Choe TB, Jang JJ, Hong SI, Lee SH

  • KMID: 2175097
  • J Korean Cancer Assoc.
  • 2000 Apr;32(2):270-278.
PURPOSE: Protein kinase C (PKC) is a family of phospholipid dependent serine/threonine protein kinases that have important role in differentiation, development and tumor promotion. PKC also has been reported to be implicated...
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