- DNA Methylation in Brain and Liver Tissues of Mice Infected with Scrapie Agent
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Choi EK, Uyeno S, Ono T, Carp RI, Kim YS
- KMID: 1551980
- J Korean Soc Virol.
- 1998 Jun;28(2):183-192.
DNA methylation degree in the several murine brain and liver genes of different ages and after scrapie infection have been examined by using methylation-sensitive restriction endonuclease digestion. We found that... -
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- Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011)
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Dobly A, Van der Heyden S, Roels S
- KMID: 1482812
- J Vet Sci.
- 2013 Mar;14(1):45-51.
- doi: 10.4142/jvs.2013.14.1.45
In sheep, susceptibility to scrapie is mainly determined by codons 136, 154, and 171 of the PRNP gene. Five haplotypes are usually present (ARR, ARQ, ARH, AHQ, and VRQ). The... -
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- Re-transmissibility of mouse-adapted ME7 scrapie strain to ovine PrP transgenic mice
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Babalola J, Kim JM, Lee YJ, Park JH, Choi HS, Choi YG, Choi EK, Kim YS
- KMID: 2454011
- J Vet Sci.
- 2019 Mar;20(2):e8.
- doi: 10.4142/jvs.2019.20.e8
Scrapie is a mammalian transmissible spongiform encephalopathy or prion disease that predominantly affects sheep and goats. Scrapie has been shown to overcome the species barrier via experimental infection of other... -
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- Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays
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Dassanayake RP, Truscott T, Zhuang D, Schneider , Madsen-Bouterse SA, Young AJ, Stanton JB, Davis WC, O'Rourke K
- KMID: 2164527
- J Vet Sci.
- 2015 Jun;16(2):179-186.
- doi: 10.4142/jvs.2015.16.2.179
Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a)... -
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