- TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation
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Pfeifer CG, Karl A, Kerschbaum M, Berner A, Lang S, Schupfner , Koch M, Angele P, Nerlich M, Mueller MB
- KMID: 2447232
- Int J Stem Cells.
- 2019 Mar;12(1):139-150.
- doi: 10.15283/ijsc18088
BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage... -
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