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Injection of Botulinum Toxin for Preventing Salivary Gland Toxicity after PSMA Radioligand Therapy: an Empirical Proof of a Promising Concept

Baum RP, Langbein T, Singh A, Shahinfar , Schuchardt C, Volk GF, Kulkarni H

The dose-limiting salivary gland toxicity of ²²⁵Ac-labelled PSMA for treatment of metastatic, castration-resistant prostate cancer remains unresolved. Suppressing the metabolism of the gland by intraparenchymal injections of botulinum toxin appears...
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Systemic Endoradiotherapy with Carrier-Added 4-[131I]Iodo-L-Phenylalanine: Clinical Proof-of-Principle in Refractory Glioma

Baum RP, Kluge A, Gildehaus , Bronzel M, Schmidt K, Schuchardt C, Senftleben S, Samnick S

  • KMID: 1447626
  • Nucl Med Mol Imaging.
  • 2011 Dec;45(4):299-307.
PURPOSE: To explore feasibility, tolerability, dosimetry and probable efficacy of intravenous endoradiotherapy with carrier-added 4-[131I]iodo-L-phenylalanine (c.a. 131I-IPA) in refractory high-grade glioma. METHODS: Two male patients (45 and 50 years), with longstanding,...
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